Endocrinology - Hypoadrenocorticism Flashcards Preview

Small Animal Medicine > Endocrinology - Hypoadrenocorticism > Flashcards

Flashcards in Endocrinology - Hypoadrenocorticism Deck (67)
Loading flashcards...
1

What are the regions of the adrenal cortex?

Zona glomerulosa, zona fasciculata, and zona reticularis

2

What does the zona glomerulosa secrete?

mineralocorticoids - think salt

3

What does the zona fasiculata secrete?

glucocorticoids - think sugar

4

What does the adrenal medulla secrete?

catecholamines

5

What does a deficiency in aldosterone (mineralcorticoid) result in?

Hypoadrenocorticism (Addison's disease)

6

What does an excess of cortisol (glucocorticoid) result in?

Hyperadrenocorticism (Cushing's)

7

What does a deficiency in cortisol (glucocorticoid) result in?

Hypoadrenocorticism (Addison's disease)

8

What stimulates the production and release of glucocorticoids from the adrenal cortex?

ACTH

9

What provides negative feedback on the pituitary gland to stop secreting ACTH?

Cortisol

10

What provides negative feedback on the hypothalamus to stop secretion of CRH?

ACTH and cortisol

11

What are the actions of glucocorticoids?

Antagonize the effects of insulin, stimulate appetite, maintain normal blood pressure/vascular tone, and maintain normal GI perfusion, motility, and mucosal integrity

12

If there is a deficiency in glucocorticoids, what is the consequence of the decreased antagonistic effect on insulin?

hypoglycemia

13

If there is a deficiency in glucocorticoids, what is the consequence of decreased appetite stimulation?

anorexia

14

If there is a deficiency in glucocorticoids, what is the consequence of decreased BP/vascular tone maintenance?

hypotension

15

If there is a deficiency in glucocorticoids, what are the consequences of altered maintenance in GI perfusion, motility, and mucosal integrity?

Vomiting, diarrhea, and weight loss

16

What is aldosterone secreted in response to?

Hyponatremia, hypotension, hypovolemia, hyperkalemia, and ACTH (minor role)

17

What chemical stimulates aldosterone secretion and from where is aldosterone secreted?

Angiotensin; aldosterone is secreted from the adrenal glands

18

How does aldosterone correct a drop in ECF/Na/BP?

It stimulates renal sodium conservation so that water is passively reabsorbed with sodium and the net result is an increase in ECF volume

19

How does aldosterone correct hyperkalemia?

It stimulates renal potassium excretion which results in blood K levels to decrease

20

What are the actions of aldosterone?

Renal excretion of potasisum, renal conservation of sodium, and renal excretion of hydrogen ions

21

If there is a deficiency in aldosterone, how is renal excretion of potassium effected?

hyperkalemia

22

If there is a deficiency in aldosterone, how is renal conservation of sodium effected?

Hyponatremia (+PU/PD)

23

If there is a deficiency in aldosterone, how is renal excretion of hydrogen ions effected?

Metabolic acidosis

24

What are the two forms of hypoadrenocorticism?

Primary and secondary

25

What is affected in primary hypoadrenocorticism?

the adrenal gland

26

What is affected in secondary hypoadrenocorticism?

the pituitary gland

27

Is primary or secondary hypoadrenocorticism more common?

primary

28

What physiologically causes primary hypoadrenocorticism?

There is a loss of functional adrenal cortical tissue - 85-90% loss before CS

29

What physiologically causes secondary hypoadrenocorticism?

Loss of ACTH stimulation to the adrenal gland

30

What are the two main etiologies of primary hypoadrenocorticism?

Immune-mediated disease and idiopathic atrophy and fibrosis
There are many other causes - basically anything that can injure the adrenal gland in any way can be a cause

Decks in Small Animal Medicine Class (100):