Flashcards in Oncology - STS, HS, Mammary Deck (79)
What are soft tissue sarcomas?
Mesenchymal tumors/spindle cell tumors - it is an umbrella term
What tumors are soft tissue sarcomas?
Fibrosarcoma, peripheral nerve sheath tumor, myxosarcoma, liposarcoma, rhabdomyosarcoma, synovial cell sarcoma, and lymphangiosarcomas
Soft tissue sarcomas are typically solitary/in multiples.
What age of dogs and cats typically get soft tissue sarcomas?
older dogs and cats
Where else, aside from the skin, can soft tissue sarcomas be seen?
GI tract, liver, and bladder possible
What is the behavior of STS?
slow growing/insidious onset
STS are __________.
a. not encapsulated
What grade of STS are more likely to recur and metastasize?
What size STS generally have a poor response to chemo and/or radiation?
Bulky tumors - >5cm
Is an FNA or a biopsy preferred for STS diagnosis?
What type of biopsy is preferred for STS diagnosis?
incisional - can be misleading
How do you need to position your biopsy for STS?
Position so that the biopsy tract is removed with surgery
What is staging for STS based on?
Minimum database, FNA local lymph node, 3 view chest rads and CT scan for surgical planning
What makes STS tumors especially difficult to excise?
They have spindles that can spread out from the tumor
What is grading of STS based on?
differentiation, mitosis, and necrosis
What treatment can be done for STS?
Wide surgery, +/- radiation therapy, +/- chemotherapy
What margins do you want for STS?
3cm lateral and 1 fascial plane
What may make it difficult to get complete excision for STS?
Less likely if >5 cm
Can STS recur after surgery?
Yes, the potential for recurrence is greater with a greater grade
If you chose not to do wide therapy for STS, what are the other options?
Amputation/hemipelvectomy or marginal excision with radiation therapy
When you take a STS out, what do you want to do before placing it into formalin?
pin it out and ink to help prevent shrinkage in formalin
What type of radiation do you want to use with STS if you got marginal excision?
Stereotactic doesn't seem to work as well
What side effects are associated with definitive radiation for STS?
Acute skin effects and a long term potential for secondary tumors
What is the chemotherapy agent of choice for STS? When is it indicated?
Indicated for grade III STS
What is the average time to metastatic disease development from STS diagnosis?
What are the negative prognostic factors for recurrence of STS?
Large tumor size, incomplete excision, and high grade
What are the negative prognostic factors for metastatic disease of STS?
Grade, necrosis, mitotic index, and local regrowth
What is the MST for dogs with a grade I STS?
What is the MST for dogs with a grade II STS?