Oncology - FISS and SCC Flashcards Preview

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Flashcards in Oncology - FISS and SCC Deck (42)
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1

What is a feline injection site sarcoma (FISS)?

A mesenchymal tumor that develops after vaccination or other SQ tissue trauma

2

What can FISS be?

FIBROSARCOMAS, rhabdomyosarcomas, malignant fibrous histiocytomas, undifferentiated sarcomas, extraskeletal osteosarcomas, chondrosarcomas, and myxosarcomas

3

What are the risk factors for FISS?

SQ killed vacciantions
SQ injections, fluids, pacemakers, and microchips

Literally any SQ insult

4

When can FISS develop post injection?

4 weeks to 10 years after the insult

5

The ____ the vaccination per site, the _____ the risk for developing a FISS.

More, higher

6

What is the pathogenesis for FISS?

Inflammation driven that leads to transformed cells

7

What clinical signs are associated with FISS?

Firm, irregular mass in the typical vaccine site
non-painful - sometimes
appears encapsulated
can be ulcerated

8

How do you diagnose a FISS?

Minimum database
Chest rads
CT/MRI
FNA
Biopsy

9

When should masses at vaccination sites be treated?

If the mass is still evident 3 or more months after vaccination
The mass is >2cm in diameter
Mass is growing 1 month after vaccine administration

10

What are the treatment options for FISS?

Surgery, radiation therapy, and chemotherapy

11

What should you not do when doing surgery for FISS?

marginal resection

12

In cases of doing surgery for FISS, what significantly reduces survival time?

marginal resection, increased number of surgical interventions, and surgery by non-referral surgeons

13

What are the recommended margins for FISS?

5 cm lateral margins and 2 fascial planes deep

14

What is the most common complication associated with intercaspular FISS?

wound dehischence - 11%

15

When is radiation indicated for FISS?

If there is marginal excision or dirty margins

16

When should radiation therapy begin in cases of FISS?

10-14 days after surgery

17

Can stereotactic radiation be used to treat FISS?

Yes - there have been studies that it can help

18

What is the metastasis rate for FISS?

20% in late disease

19

If you decide to use chemotherapy for FISS, what agent should you use?

Doxorubicin
Backup - mitoxantrone, vincristine

20

What prognostic factors are associated with FISS?

FeLV status - + is worse
Histologic grade
Site
Aggressive surgery

21

What is the behavior of FISS?

They are very aggressive

22

What are the most common oral tumors in cats?

Squamous cell carcinomas

23

What is the recommended treatment for feline oral tumors?

surgery if possible

24

What chemotherapy agent can be used for feline oral tumors?

Palladia

25

True or False: Feline oral SCC often involve the local bones

true

26

What does prognosis for oral SCC depend on?

Size and surgery

27

Can oral melanoma happen in cats?

yes, but it is rare

28

What is the metastatic rate for feline oral melanoma?

high- 66%

29

What treatments can be done for feline oral melanoma?

Surgery, radiation therapy, and carboplatin

30

What are eosinophilic granulomas?

Rodent ulcer/indolent ulcer that is no cancerous

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