Flashcards in Oncology - Oral and Nasal Deck (65)
What is the most common oral tumor in the dog?
What oral tumors do dogs get?
Melanoma, SCC, fibrosarcoma, acanthomatous ameloblastoma
What nasal tumors do dogs get?
What history is often associated with oral tumors in dogs?
Halitosis, blood in the water bowl, ptyalism, dysphagia, and hyporexia
When you are trying to diagnose canine oral tumors, what do you want to examine in the mouth?
Mandible, maxilla, palate, tongue, under the tongue, tonsils, and palpate under the mandible and between the rami
True or False: All oral tumors look the same.
False - they can be raised, pignmented, ulcerated, smooth, and friable
What is the first diagnostic test you want to do, aside from PE, when you have an oral neoplasia?
You should aspirate one/both regional LN in patients with an oral mass.
both - even if they could look normal
True or False: FNA is better for diagnosing oral tumors.
False - biopsy is best
What imaging methods should you do if you are dealing with an oral tumor?
Chest x-rays to look for metastasis, +/- dental rads, and CT scan
Oral malignant melanomas are tumors of the _______.
Where are oral melanomas most commonly seen?
Gingiva, lips, tongue, and hard palate
True or False: Not all oral melanomas are pigmented
true - 1/3 of them are not
How do oral melanomas typically look in the mouth (not color)?
ulcerated and necrotic
What does the biological behavior of oral melanomas depend on?
size, site, and histologic parameters
Oral melanomas are ______ invasive with a high _______ potential.
How can oral melanomas be treated?
Surgery, radiation, chemotherapy, COX 2 inhibition, and the melanoma vaccine
Does a patient have a better prognosis if it gets surgery alone or surgery with radiation therapy?
surgery with radiation therapy
Does the stage of oral melanoma affect the survival time?
Yes, the worse the stage, the shorter survival time
What are some negative prognostic factors for oral melanomas?
Incomplete surgical margins, locations, and surgery alone
Is radiation alone or radiation with surgery associated with a longer survival time in oral melanoma patients?
radiation with surgery
What is the only chemotherapy that oral melanoma is responsive to?
Carboplatin - still not very responsive
What drug can inhibit COX2 and aid in treatment of oral mealnoma?
What stages of oral melanoma is the melanoma vaccination licensed for?
stage II/III with local control
True or False: The oral melanoma vaccination can be used to prevent oral melanoma.
What is the oral melanoma vaccination made out of?
Gene for human tyrosinase is inserted into a DNA plasmid
What does the oral melanoma vaccination do?
Stimulates the immune system to the presence of the tyrosinase and targets melanoma cells
Large/small breeds more often get canine fibrosarcoma.
60-72% of fibrosarcomas have ____ involvement.