Oncology - Osteosarcoma and Hemangiosarcoma Flashcards Preview

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Flashcards in Oncology - Osteosarcoma and Hemangiosarcoma Deck (60)
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1

What is an osteosarcoma?

It is a malignant mesenchymal tumor of primitive bone that produces an extracellular osteoid matrix

2

True or False: Osteosarcoma is the most common skeletal malignancy in dogs.

True

3

What type of age distribution does osteosarcoma have?

Bimodal - young dogs, and old dogs

4

What breeds more commonly get osteosarcomas?

Large/Giant Breed dogs

5

What legs usually get osteosarcomas more commonly?

Front legs

6

Where do osteosarcomas more commonly happen?

at the metaphysis

7

What are the developmental factors that can lead to osteosarcoma?

Large, fast growing dogs
Dogs who get ionizing radiation

8

How are osteosarcomas diagnosed?

Radiographs primarily

9

Is cytology or a biopsy necessary for osteosarcoma diagnosis?

It has decent accuracy of determining malignancy and an average accuracy of determining tumor type Can fracture

Long story short - not entirely necessary

10

Is a definitive diagnosis of osteosarcoma needed before treatment?

no - any other lesion that could be caused there may be treated similarly
If you are doing radiation - no

11

What should be done for staging?

3 view chest rads
LN aspirate
Bone scan is not helpful

12

What percentage of cases have micrometestatic disease at diagnosis of osteosarcoma?

90%

13

What is osteosarcoma grading based on?

Amount of pleomorphism, tumor cell appearance, MI, and necrosis

14

What grade of osteosarcoma has the highest risk of death

Grade III

15

What are subclassifications of osteosarcoma based on?

the type and amount of matrix, may impact survival

16

What is a stage I OSA?

Low grade, no metastasis

17

What is a stage II OSA?

high grade, no metastasis

18

What is a stage III OSA?

Low or high grade, mets

19

What is a stage A OSA?

Intracompartamental

20

What is a stage B OSA?

Extracompartamental

21

What stage and grade are most dogs that we diagnose with OSA?

Stage IIB

22

What are the treatment options for OSA?

Surgery, radiation, chemotherapy, and pain control

23

What is the recommended surgery for OSA?

Amputation - this does nothing for the metastasis
Limb spare

24

What is limb spare?

You take the tumor out and replace it with something - can only do for distal radial osteosarcoma

25

What radiation therapy options are there for osteosarcoma?

Palliative and stereotactic

26

What is something important to keep in mind about stereotactic therapy and OSA?

The leg will fracture within a year

27

What is the chemotherapy of choice for OSA?

Carboplatin (less side effects) or doxorubicin

28

What can be done to remove pulmonary metastatic disease associated with OSA?

pulmonary metastasectomy

29

What criteria are there for pulmonary metastasectomy?

Stable primary disease for 300 days
3 lesions or less
Radiographic doubling time for >40 days
No other evidence of disease

30

What pain control can be given to manage OSA?

NSAIDs, Opioids, Gabapentin, and bisphosphonates

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