Oncology - Lymphoma/Leukemia 2 Flashcards Preview

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Flashcards in Oncology - Lymphoma/Leukemia 2 Deck (90)
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1

Define stage I lymphoma.

Involvement of LN or organ

2

Define stage II lymphoma.

Involvement of 1 or more regional lymph nodes

3

Define stage III lymphoma.

Generalized LN involvement

4

Define stage IV lymphoma.

Liver/spleen involvement

5

Define stage V lymphoma.

Bone marrow involvement or other organs

6

Define substage A.

Healthy - absence of significant clinical signs

7

Define substage B.

Sick - clinical signs attributable to systemic disease

8

True or False: Stage I-IV have a similar prognosis.

True

9

Which substage has a worse prognosis?

substage B

10

What are the diagnostic methods that can aid in staging?

Minimum database
Thoracic radiographs
Abdominal rads and/or ultrasound

11

If you are going to do the bare minimum for staging, what tests should be done?

CBC, chemistry, and UA

12

*A dog with lymphoma being presented with peripheral lymphadenopathy and uveitis would be classified with what stage of disease?
a. Stage 1
b. Stage 2
c. Stage 3
d. Stage 4
e. Stage 5

*his question

e. Stage 5

13

What are the different types of immunophenotyping that can determine the difference between B cell or T cell lymphoma?

Immunohistochemistry
Immunocytochemistry
Flow cytometry
PARR

14

What is the gold standard for immunophenotyping between B and T cell lymphoma?

Immunohistochemistry

15

What samples do immunohistochemistry use?

Histopathology/biopsy sample

16

What samples do immunocytochemistry use?

cytology

17

What are the advantages of knowing if it is B cell or T cell lymphoma?

Prognostic indicator
May change treatment options

18

How do you test for lymphocyte clonality?

PCR for antigen receptor rearrangement

19

What does a polyclonal PARR response indicate?

reactive

20

What does a monoclonal PARR response indicate?

neoplastic

21

What is PARR performed on?

Blood, bone marrow, lymph node aspirates, effusion, and mediastinal mass

22

What does PARR test for?

clonality to distinguish reactive lymphocytosis vs. lymphoma (slide says leukemia but I feel like its a typo)

23

What is flow cytometry performed on (in the context of lymphoma)?

Blood, bone marrow, LN, effusion, and mediastinal mass

24

What does flow cytometry test for?

a panel of antibodies - phenotype, subtype, MHCII, etc.

25

What percentage of lymphoma cases are B cell?

2/3 (66%)

26

Does B cell or T cell lymphoma have a better prognosis?

B cell lymphoma

27

Where are T cell lymphomas commonly found?

Skin, mediastinum, GI, and hepatic

28

Does B cell or T cell lymphoma have a better response to the CHOP protocol?

B-cell

29

*Which one of the following lymphoma diagnostics evaluates clonality of the lymphocyte population?
a. PARR
b. Flow cytometry
c. Immunohistochemistry
d. Immunocytochemistry

a. PARR

30

Generally, what factors indicate prognosis in lymphoma?

Stage of disease, Substage, immunophenotype, anatomic form, prior prednisone use, histologic grade, hypercalcemia, anemia, and chemotherapy induced hematologic toxicity

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