Endocrinology - Cushings 1 Flashcards Preview

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Flashcards in Endocrinology - Cushings 1 Deck (62)
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1

What is Cushing's?

Hyperadrenocorticism

2

What does HAC mean?

Hyperadrenocorticism

3

What does PDH mean?

pituitary-dependent hyperadrenocorticism

4

What does ADH mean?

adrenal dependent hyperadrenocorticism

5

What is an FAT?

Functional adrenal tumor

6

What is LDDST?

Low dose dexamethasone suppresion test

7

What is HDDST?

high dose dexamethasone suppression test

8

What is HPA?

hypothalamic-pituitary-adrenal axis

9

What is the catabolic role of glucocorticoids?

Accelerate protein break down and inhibit DNA, RNA, and protein synthesis

10

What roles do glucocorticoids have in metabolism?

Increase gluconeogenesis, increase fatty acid metabolism, stimulate muscle catabolism, prevent muscle and fat uptake of glucose, oppose the actions of insulin, and increase glycogen storacge

11

How do glucocorticoids act on the CNS?

Appetite stimulation

12

How do glucocorticoids act on the vasculature?

maintain normal BP and constrict the vasculature

13

How do glucocorticoids act on the GI tract?

They maintain normal perfusion and motility

14

How do glucocorticoids act on the inflammatory/immune systems?

They keep neutrophils in the blood vessels and inhibit their function, inhibit inflammation, and inhibit wound healing

15

What renal effects do glucocorticoids have?

Inhibit ADH action at the kidney (nephrogenic diabetes insipidus) and PU/PD

16

What is hyperadrenocorticism?

chronic excess of circulating glucocorticoids

17

What are the '3 flavors' of Cushing's?

Pituitary depended hyperadrenocorticism, functional adrenal tumors, and iatrogenic disease

18

What causes PDH?

A pituitary tumor - microadenomas or macroadenomas

19

What is another term for functional adrenal tumors?

adrenal dependent hyperadrenocorticism

20

What can cause iatrogenic Cushing's?

exogenous glucocorticoid administration

21

What is the signalment for Cushing's?

Middle to older aged dogs - poodles, boxers, and dachschunds are overrepresented

22

What size dog typically gets PDH?

Small breed dogs

23

What are the high risk breeds for ADH?

GSD, Daschund and Labrador retriever

24

What are the common signs associated with Cushing's?

THEY ARE SLOW ONSET - Polydipsia, polyuria, polyphagia, pot-bellied, hair loss, skin infections, panting, muscle weakness, and lethargy

25

What are the not so common but common signs associated with Cushing's disease?

Various cutaneous changes, myotonia, and CNS signs

26

True or False: Dogs with Cushing's are not generally sick

TRUE

27

What conformational changes are associated with Cushing's?

hepatomegaly, abdominal muscle weakness, increased intra-abdominal fat, and muscle atrophy which results in pendulous abdomen

28

What cutaneous changes are associated with Cushing's?

Symmetrical alopecia, comedones, hyperpigmentation, and scaling

29

What signs are associated with pituitary macroadenoma syndrome?

Lethargy, listlessness/dullness, aimless wandering, head pressing, behavioral alterations, seizures, circling, and ataxia

30

How do you diagnose Cushing's?

History, PE findings, clinical pathology data, and adrenal function tests

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