Endocrinology - Hypothyroidism Flashcards Preview

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Flashcards in Endocrinology - Hypothyroidism Deck (60)
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1

What does TBG stand for?

thyroid hormone binding globulin

2

What does TSH stand for?

thyroid stimulating hormone - thyrotropin

3

What does TRH stand for?

Thyrotropin releasing hormone

4

What does T4 stand for?

Thyroxine

5

What does TgAA stand for?

Thyroglobulin antibodies

6

What does T4AA stand for?

T4 autoantibodies

7

What does NTI stand for?

non-thyroidal illness

8

What does ED stand for? (in relation to the thyroid not male pee pee issues)

equilibirum dialysis

9

What does RIA stand for?

radioimmunoassay

10

The thyroid hormone has a lot of functions. It is important to keep in mind that ___ ______ ______ escapes the adverse effects of excess or insufficiency.

No organ system

11

What is the major secreted thyroid hormone?

T4

12

What is the major biologically active thyroid hormone?

T3

13

Is T3 or T4 more potent?

T3

14

What form of hormone, bound or unbound, is biologically active and able to mediate regulatory feedback?

The unbound (free) form

15

What are the 2 major categories of primary hypothyroidism?

Lymphocytic thyroiditis or idiopathic thyroid degeneration

16

What is lymphocytic thyroiditis?

Lymphocytic infiltration with progressive destruction of thyroid follicles

17

How can inflammation in cases of lymphocytic thyroiditis be measureD?

In the serum by measuring antibodies to thyroid components - usually thyroglobulin

18

True or False: You will see clinical signs well before extensive damage by lymphocytic thyroiditis occurs.

False - extensive destruction occurs before clinical signs of hypothyroidism develops

19

What is idiopathic thyroid degeneration?

Loss of thyroid parenchyma and then replaced by adipose and fibrous tissue

20

What breeds are over represented by hypothyroidism?

Doberman, golden retriever, labrador retriever, and cocker spaniel

21

When do clinical signs due to hypothyroidism typically develop?

in middle aged animals

22

What general clinical signs are associated with hypothyroidism?

Decreased metabolic rate, skin/haircoat changes (most common), neurologic, ocular, and myxedema coma

23

What clinical signs are associated with decreased metabolic rate?

lethargy, dullness, weight gain without polyphagia

24

What skin/haircoat changes are associated with hypothyroidism?

Alopecia, hyperpigmentation, and pyoderma

25

What neurologic clinical signs are associated with hypothyroidism?

Peripheral neuropathy, central vestibular disease, subclinical myopathy, and less commonly (seizures, laryngeal paralysis, megaesophagus, MG, and others)

26

What ocular clinical signs are associated with hypothyroidism?

corneal lipid

27

What is a myxedema coma?

life-threatening hypothermia, bradyarrhythmias, and rapid deterioration in the mental state

28

What clinical pathology is associated with hypothyroidism?

Normocytic, normochromic, non-regenerative anemia (30% of dogs), hypercholesterolemia (75% of dogs), hypertriglyceridemia, and a normal UA

29

What thyroid screening test is used to rule out hypothyroidism?

Total thyroxine (TT4)

30

What forms of T4 does TT4 screen for?

bound and unbound

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