Oncology - Intro + Lymphoma Flashcards Preview

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Flashcards in Oncology - Intro + Lymphoma Deck (66)
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1

True or False: Cancer is a leading cause of death for dogs and cats.

True

2

What are some things that clients will want to know when you tell them their animal has cancer?

Diagnosis, prognosis, quality of life, treatment options, cost, and 'what to do'

3

Multimodal treatment is often need for neoplasia. What are the four main treatments?

Chemotherapy, surgery, radiation, immunotherapy

4

What are some general categories that you need to know when treating neoplasia?

What is it? Cytology, biopsy
Where is it? Location, staging
How is it likely to behave? locally, systemically
Treatment options
Expected outcomes/prognosis
Clients' goals/expectations

5

What are the most common side effects of chemotherapy?

Myelosuppression and GI side effects

6

How does myelosuppression due to chemotherapy present?

neutropenia and thrombocytopenia

7

What GI signs are side effects of chemotherapy?

Vomiting, inappetence, and diarrhea

8

Hair loss is an uncommon side effect of chemotherapy. However when it does occur, what breeds are more affected?

Breeds with continual hair growth

9

____% of chemotherapy patients experience some level of side effect(s).

~30%

10

~___-___% of patients that experience chemotherapy side effects are severe enough to require hospitalization.

~5-10%

11

What % of chemo side effects are severe enough to be life-threatening?

<1%

12

If your patient is febrile/neutropenic due to chemotherapy, what is the recommended treatment?

IV antimicrobials

13

If your patient is dehydrated due to chemotherapy, what is the recommended treatment?

IV fluid therapy

14

What antiemetic works on the emetic center?

Cerenia

15

What antiemetic works on the chemoreceptor trigger zone?

Cerenia and metaclopramide

16

What antiemetic works on the afferent neurons?

Ondansetron

17

What is the antiemetic protocol for in-hospital chemotherapy patients?

Ondansetron 0.5 mg/kg SC 30 minutes prior to chemotherapy

18

What is the antiemetic protocol for at-home chemotherapy patients?

Cerenia 2 mg/kg PO q24 hours for 5 days

19

What are the rescue options for breakthrough vomiting in chemotherapy patients?

Ondansetron
Metoclopramide
Mirtazapine

20

Cerenia (maropitant) treats vomiting by preventing the binding of which ligand to its respective receptor in the emetic center?
a. Serotonin to 5HT3
b. Dopamine to D2
c. Substance P to NK1
d. Histamine to H2

c. Substance P to NK1

21

_______ is a key indicator of quality of life. It is often the first or only sign a pet is not feeling well.

Appetite

22

_______ is considered an acceptable side effect, but ______, ______ ____ and depression are considered unacceptable.

Vomiting, inappetence, and weight loss

23

What type of drug is mirtazapine?

Noradrenergic and specific serotonergic antidepressant

24

What does mirtazapine do on a physiological level?

Stimulates 5-HT1 receptors
Strongly antagonizes 5-HT2 and 5-HT3

25

On a clinical level, what does mirtazapine do?

Decreases nausea/vomiting, appetite stimulant, and possible prokinetic effect

26

What animal is Mirataz (mirtazapine transdermal ointment) FDA approved for use in?

Cats

27

What is the indication for Mirataz?

Management of weight loss in cats

28

What animal is Entyce (capromorelin oral solution) FDA approved for use in?

Dogs

29

What does entyce mimic the action of? What does that do?

Ghrelin - effect at appetite center to increase food intake

30

What type of drug is entyce?

Potent and selective GHSR agonist to increase growth hormone secretion

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