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Flashcards in Cardio - Lab Testing Deck (31)
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1

T/F: Routine labwork is generally useful for the diagnosis of cardiac disease

False

2

What is routine labwork useful for?

To screen for concurrent diseases that can affect the CV system or complicate tx of the disease

3

What are some concurrent diseases that can be seen on routine labwork?

Hyper/hypothyroidism, CKD, hyper/hypoadrenocorticism, anemia/polycythemia, hyperaldosteronism, SIRS/sepsis

4

Routine labs are useful to monitor for _____ of cardiac meds.

side effects

5

What are the routine labs?

CBC, chem, U/A, T4

6

What common CV meds are concerning and why?

Furosemide, enalapril, benazepril, spironolactone;

We are dehydrating our patients on purpose, i.e. causing increased renal values and electrolyte abnormalities

7

What does furosemide alter?

Increases BUN/crea and bicarb

Decreases Cl, K, Mg, Na

8

What does enelapril/benazepril and spironolactone alter?

Increases BUN/crea and K+

9

What test cannot be used to monitor renal function in patients receiving diuretics?

USG - we already know the pet is isosthenuric

10

What is cTnI?

Protein attached to actin/tropomyosin in the cardiac sarcomere

11

cTnI is a _____ protein and is released when myocytes are _____.

leakage, damaged

12

What is cTnI sensitive and specific for?

myocardial injury

13

What can cTnI NOT specify?

What caused the injury

14

What is the normal range for cTnI?

< 0.2 ng/ml (check with lab)

Should not see free range in blood; if see this it means there is myocyte damage

15

What cardiac conditions may cause an increase in cTnI?

Myocarditis, thoracic/cardiac trauma, cardiotoxicity, cardiac HSA in dogs, occult DCM in Dobermans, severe heart disease/CHF in dogs and cats

16

What are some non-cardiac decreases with which we may see increased cTnI?

CKD (decreased GFR), GDV, IMHA, anemia

17

When might you use a cTnI test (in general)?

Patients with a clinical suspicion of myocarditis

18

When might you use the cTnI test in dogs?

Pericardial effusion (when no mass is seen on echo);

Asymptomatic Dobermans

19

When might you use the cTnI test in cats?

Dyspneic cats (CHF vs. resp disease), HCM

20

What is NT-proBNP?

(B-type natriuretic peptide)

Hormone synthesized and released from the ventricles in response to myocardial stretch

21

What does NT-proBNP cause?

Diuresis, natriuresis, vasodilation

22

NT-proBNP is naturally anti-_____.

RAAS

23

NT-proBNP is the inactive form of _____.

C-BNP

24

What value does Idexx use?

NT-proBNP

25

What value does Antech use?

C-BNP

26

What cardiac diseases can cause an increase in NT-proBNP?

DMVD, DCM, HCM

27

Magnitude of NT-proBNP increase correlates with _____ of heart disease.

severity

28

What non-cardiac diseases cause NT-proBNP elevation?

Day-to-day variation, CKD (decreased GFR), critical illness, PHT

29

When might you use a NT-proBNP test in cats?

Asymptomatic cats with murmurs, dyspneic cats

30

What type of NT-proBNP test has a higher cutoff value and when might you use it?

Bedside SNAP test (~220 pmol/L);

used in dyspneic cats to determine CHF vs. respiratory disease

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