Hematology - Hemostasis 2 Flashcards Preview

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Flashcards in Hematology - Hemostasis 2 Deck (82)
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1

______ is needed for medium/large vessels.

Fibrin

2

What cells are key players for secondary hemostasis?

Platelets and fibroblasts

3

What proteases are involved in secondary hemostasis?

FXIa, FIXa, Fxa, FIIa, and FVIIa

4

What cofactors are involved in secondary hemostasis?

Tissue factor (FIII), FVa, and FVIIIa

5

What crosslinkers are involved in secondary hemostasis?

FXIIIa

6

What activators are involved in secondary hemostasis?

Vitamin K

7

What inhibitors are involved in secondary hemostasis?

Antithrombin, protein C, and protein S

8

What is the end result of secondary hemostasis?

Generation of thrombin which forms a crosslinked fibrin clot

9

Secondary hemostasis is a series of enzymatic reactions involving what three main things?

Coagulation factors, calcium, and Phosphatidylserine on platelets

10

What does thrombin (FIIa) do?

It cleaves fibrinogen (FI) into fibrin

11

How does fibrin form the fibrin clot?

It is cross-linked to form the fibrin clot by FXIIIa

12

What is the extrinsic pathway composed of?

Tissue factor (TF), FVII, and calcium

13

What is the intrinsic pathway composed of?

FXII, FXI, and FIX, FVIII, calcium, and phosphatidylserine

14

What is the end result of the intrinsic pathway?

FIXa and cofactor FVIIIa to activate X into Xa

15

What factors are involved in the common pathway?

Fxa, prothrombin (FII), FXIII (crosslinker), FV, calcium, and phosphatidylserine

16

What tests assess the functionality of both the intrinsic and common pathways?

Activated partial thromboplastin time (aPTT) and activated coagulation time (ACT)

17

What test assesses the functionality of the common pathway alone?

Thrombin clot time (TCT)

18

What tests assess the functionality of both the extrinsic and common pathways?

Prothrombin time (PT) and PIVKA

19

What is involved in the initiation phase of the cell-based model?

Extrinsic pathway, tissue factor, and the cell surface of fibroblasts

20

What is involved in the amplification phase of the cell-based model?

Intrinsic factor, thrombin, and the cell surface of the platelet

21

What cell surface is associated with the propagation phase of the cell-based model?

the platelet

22

What are the functions of thrombin?

Activation of the intrinsic patway (FXI, FVIII, and FV to make more thrombin), activation of FXIII to crosslink fibrin, cleaves fibrinogen into soluble fibrin, and activation of platelets for more surface for the intrinsic pathway

23

Which model of secondary hemostasis explains what goes on in the body better?

the cell based model

24

What can go wrong with secondary hemostasis?

Too few or too many coagulation factors and antagonized or inactive vitamin K

25

What are the inherited coagulation disorders?

Hemophilia A and B

26

What coagulation factor is deficient in hemophilia A?

FVIII (8) deficiency

27

What coagulation factor is deficient in hemophilia B?

FIX (9) deficiency

28

What are the acquired causes of coagulation disorders?

Anticoagulant rodenticide, DIC, and Liver disease

29

How does DIC result in a coagulation disorder?

it consumes clotting factors

30

How does liver disease result in a coagulation disorder?

There is not enough production of clotting factors

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