MACROLIDES Flashcards
1
Q
what are the macrolides?
A
erythromycin (IV/PO)
clarithromycin (PO)
azithromycin (IV/PO)
fidaxomicin (PO)
bacteriostatic, time dependent
2
Q
ribosomal subunit affected?
A
50s
3
Q
good against?
2nd line option against?
A
atypicals
-legionella, chlamydophilia, mycoplasma
t. palladium and borrelia burgdorferi
4
Q
clinical uses?
A
resp chlamydial infections gastroparesis -erythromycin H. pylori ulcers Mycobacterium avium complex
5
Q
QT prolongation?
A
yes
ototoxicity with IV infusion of erythromycin
hepatic
GI
6
Q
potent inhibitors of CYP3A4? which one is the exception?
A
erythromycin and clarithromycin
azithromycin
7
Q
indication of fidaxomicin?
A
C dif
inhibits RNA polymerase, bactericidal
