DIURETICS PHARMACOLOGY II Flashcards

1
Q

potassium sparing diuretics discussed in class?

A

spironolactone/Eplerenone

amiloride/triamterene

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2
Q

spironolactone/Eplerenone MOA?

A

inhibits aldosterone effects in the cortical collecting tubule and late distal tubule

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3
Q

amiloride/triamterene MOA?

A

inhibits sodium transport through ion channels in the cortical collecting tubule and late distal tubule

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4
Q

potassium sparing diuretics (spironolactone/Eplerenone )side effects?

A
hyperkalemia
gynecomastia
constipation
hypotension
rash
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5
Q

potassium sparing diuretics, amiloride, side effect?

A
hyperkalemia
headache
diarrhea
abdominal discomfort
decrease appetite
impotence
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6
Q

potassium sparing diuretics, triamterene, side effect?

A

hyperkalemia
hyponatremia
GI disturbances
megaloblastic anemia

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7
Q

indications for eplerenone?

A

hypertension

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8
Q

spironolactone indicatons?

A
hypertension
primary aldosteronism
hypokalemia
edema secondary to cirrhosis***
heart failure
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9
Q

amiloride indications?

A

hypkalemia

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10
Q

triamterene indications?

A

hypokalemia

edema

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11
Q

spironolactone/eplerenone contraindications?

A

hypersensitivity to spironolactone

moderate to severe renal dysfunction

hyperkalemia

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12
Q

amiloride contraindications?

A

hyperkalemia

severe renal dysfunction

hypersensitivity to amiloride

moderate to severe hepatic dysfinction

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