MMD DRUGS- MISC ANTIDEP

Question 1

First line for MDD (also social anxiety disorder, and smoking cessation)

MECH

• no 5-HT affect just DA and NE
• -less sexual dysfunction

adverse effect
-dose related seizures*

Answer 1

bupropion

Question 2

First line for MDD

MECH
-central alpha-2 receptor antagonist to increases in NE and HT

uses

• Increase appetite and weight gain in elderly
• sedation effects so good for insomnia

adverse effects
-may pro long QT when overdosed

Answer 2

mirtazapine

Question 3

• inhibits serotonin transporters and 5-HT2A receptors
• sedation
• orthostatic hypotension

used for sedation effects
-adverse effect priaprism

Answer 3

trazadone

Question 4

Sleep paralysis possible

similar efficacy to SSRIs?

Answer 4

Vilazodone

Vortioxetine

Question 5

adverse effects?

Answer 5

SIADH
Sexual dysfunction
Discontinuation Syndrome
Serotonin Syndrome

Question 6

this adverse effect causes hyponatremia

drug causes in TCA, SSRIs, SNRIs

lethargy headache, insomnia, nervousness

Answer 6

SIADH

Question 7

the sexual dysfunction is due to?

management?

Answer 7

serotonergic effects

reduce dose/switch
serotonin antagonist- cyproheptadine

Question 8

what are the signs and symptoms of discontinuation syndrome?

Answer 8

finish

flu
insomnia
nausea
instability
sensory disturbances
hyperarousal

Question 9

this syndrome has altered status

autonomic dysregulation

neuromuscular abnormalities

*too much serotonergic agonism

Answer 9

serotonin syndrome