ANTIBIOTICS III Flashcards
sulfamethoxazole interferes with folic acid synthesis and growth by inhibiting formation of dihydrofolic acid
THF acid formation
what folate antagonist is this? and the type of effect due to inhibition
trimethoprim/sulfamethoxazole
synergistic effect
trimethoprim/sulfamethoxazole, is a good spectrum against?
S. aureus
MRSA
H. Influenzae
what is the effect of trimethoprim/sulfamethoxazole on warfarin?
what is the preg cat?
increases IN/prothrombin time (avoid if possible)
Cat C, safe in breastfeeding
what are the aminoglycosides?
used for?
how is metabolism?
tobramycin
amikacin
gentamicin
neomycin
drug resistant organisms, bactericidal inhibitors of protein synthesis
renal adjustment is important
aminoglycosides combine with what to get past the cell wall enhancing aminoglycoside transport?
PCN, Vanco
therapeutic monitoring of aminoglycosides?
killing power increased by maxing the peak:MIC ratio
what is safety monitoring for aminoglycosides?
good spectrum? moderate?
time and concentration dependent
time above threshold is critical
gram negative, moderate against Staph(inc MRSA)
what are the aminoglycosides used for?
T/F, neomycin is nephrotoxic?
life threatening infections and/or resistant bacteria
T
ADRs of Aminoglycosides?
ototoxicity
nephrotoxicity
neurologic
preg risk in Cat D
what is the effect of extended dosing of aminoglycosides?
decreases risk of ADRs
new AMG that is less susceptible AMG modifying enzymes
spectrum against
- E. coli
- K. pneumoniae
- proteus
- E. colacae
plazmocin
