BENZODIAZEPINES

Question 1

what is the mech?

indicated for?

Answer 1

Binds to GABA (inhibitory NT) receptoràpotentiates endogenous GABA to its
receptoràneuronal depression

anxiety
epilepsy
alcohol W/D

controlled 4 substance

Question 2

what is the risk?

Answer 2

physical and psychological dependence

discontinuation can result

Question 3

metabolism of these three drugs, also do not undergo CYP metabolism; they go though phase 2 conjugation?

Answer 3

Lorazepam, Oxazepam, Temazapam

Question 4

useful for which type of peoples?

Answer 4

hepatic impairment
elderly
alcoholics

Question 5

pregnancy risk?

Answer 5

cat D or X

Question 6

WD characteristics, common symptoms?

others?

Answer 6

anxiety, insomnia, restlessness, muscle tension, irritability

tinnitus, hallucinations, seizures

Question 7

used for GAD

affinity for 5-HT1A and 5-HT2 receptors

onset 3-4 weeks

just as effective as Benzodiazepines for for GAD, anxiolytic

no dependence issues or CNS depression

Answer 7

Buspirone (kind of in a class of its own)