LAST MINUTE MIGRAINE PROPHYLAXI

Question 1

what are the options?

Answer 1

beta blockers
tricyclic depressants
anticonvulsants
NSAIDs

Question 2

reduces frequency 50% in more than half of the patients

modulates adrenergic and serotonergic tone making patients less susceptible to migraines

preferred in HTN or angina

proponolol

Answer 2

beta blockers

Question 3

down regulates serotonin and NE receptors

TCAs are associated with more side effects therefore tolerability may prevent use

preferred if patient has depression or insomnia

amitriptyline

Answer 3

tricyclic antidepressants

Question 4

increases GABA to brain neurons and may enhance GABA at postsynaptic receptor sites

potential side effects; both teratogenic

seizure disorder or bipolar illness

divalproex
topiramate

Answer 4

anticonvulsants

Question 5

used sparingly

predictable migraines, menstrual associated

initiate 1-2 days prior

Answer 5

NSAIDs

Question 6

what are cluster headaches treated with?

Answer 6

100% oxygen

Question 7

galcanezumab
epitinezumab
erenumab
fremanezumab
*monoclonal antibodies that bind to this specific peptide?

Answer 7

CGRP

calcitonin gene related peptide