SCHIZOPHRENIA Flashcards

1
Q

what is this hypothesis?

drugs that increase dopamine can cause psychosis so blocking dopamine receptors is the clinical efficacy

A

dopamine hypothesis

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2
Q

treatment approach/goals

pretreatment?
goals?

A
  • mental status exam
  • neuro exam
  • exclude causative agents like-cocaine, amphetamines, LSD, corticosteroids

acute stabilization
stabilization
maintenance

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3
Q

positive symptoms like delusions, hallucinations, disorganized speech, disorganized behavior are related to increased dopaminergic activity in the?

A

mesolimbic region

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4
Q

negative symptoms like affective flattening, alogia, avolition, anhedonia are related to decreased dopaminergic activity in the?

A

mesocortical region

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5
Q

for this, in terms of creatine, what must be considered and excluded?

A

drugs

  • cocaine
  • amphetamines
  • LSD
  • corticosteroids
  • methylphenide
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6
Q

treatment goals occur in what phases?

A

acute stabilization
stabilization
maintenance

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7
Q

antipsychotic uses?

A
schizophrenia
bipolar
psychotic depression
psychoses
drug induced psychosis
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8
Q

first gen antipsychotics are considered?

A

typical antipsychotics

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9
Q

second gen antipsychotics are considered?

A

atypical antipsychotics

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10
Q

FGA MOA?

how do agents differ?

A

decreases central DA neurotransmission through D2 blockade also antagonizes muscurinic cholinergic, a2, H1 receptors

based on potency and side effects

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11
Q

FGA low potency?

FGA high potency?

A

chlorpromazine
thioridazine

fluphenazine
haloperidol

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