MMD DRUGS- MAO-I

Question 1

what the important MAO-Is?

Answer 1

TIPS

tranylcypromine
phenelzine
isocarboxazid
selegiline

Question 2

transdermal selegiline used for what only?

oral selegiline is indicated for?

this can cause a false positive drug screen?

Answer 2

depression

parkinson disease

L-amphetamine metabolite

Question 3

what is the mech?

Answer 3

Binds MAO-A and MAO-B à increases in endogenous concentrations of 5-HT, NE and DA

Question 4

what is this reserved for?

Answer 4

Reserved for patients not responding to other antidepressents (due to lots of side effects)

Question 5

warnings and precautions?

Answer 5

Serotonin syndrome

Suicidal thinking/behavior

Hypertensive crisis

Question 6

in transitioning to/from MOA-I what must the patient complete?

MAO-I to another depressant?

most antidepressants to MAO-I?

fluoxetine to MAO-I?

Answer 6

“washout period”

2 weeks
2 weeks
5 weeks

Question 7

major adverse effects?

Answer 7

orthostatic hypotension

Question 8

drug interaction contraindications?

Answer 8

stimulants like amphetamines

Question 9

black box warning?

Answer 9

serotonin syndrome

suicidal thinking

OD

hypertensive crisis

discontinue 10 days before elective surgery

Question 10

what can cause MAO-I hypertensive crisis?

Answer 10

tyramine

drug interactions with sympathomimetics

Question 11

MAO-A degrades?

Answer 11

NE and 5-HT