Flashcards in Hyperlipidemia General Info Deck (12)
How do we optimize the prevention of heart disease?
Lipid-lowering drugs combined with diet changes and exercise
Main HD risk profiles from a lipid standpoint
-Most cholesterol is carried in LDL particles
-Increased TGs and decreased HDL also a risk factor
-Trans Fat Acids (TFAs)
Components of Hyperlipidemia prevention
-Mediterranean diet has the best data (DON'T advocate for that stupid stupid "low-fat diet")
Historically we have classified lipoprotein abnormalities into what two groups?
1. Increased LDL
2. Combined dyslipidemia: Low HDL, high TG, high non-HDL, and normal LDL
The new approach for LDL targets is NOT based on specific LDL goals. What is the focus?
-Statin trials used specific doses; they didn't titrate to a specific LDL goal
-New focus is on an LDL % reduction
Focus is on more statin use and less use of non-statins
ACC/AHA CVD Risk Calculator purpose
-Determines patients 10-year risk of AMI or CVA based on sex, race, total, and HDL cholesterol, DM, systolic BP, HTN, smoking status
"High Intensity" Statins
-Lower LDL by >50%
Moderate Intensity Statins
-Lower LDL by 30-49%
-Literally all the other statins
The guidelines recommend treating LDL in what patients?
1. Clinical ASCVD
3. LDL >190
4. 10-year ASCVD risk >20%
5. 10-year ASCVD risk of 7.5-19.9% in the presence of RF or mild coronary artery calcium
Common causes of secondary hyperlipidemia?
-Obstructive biliary disease
-Always rule these out if the initial LDL evaluation is >190
Lipid screening in pediatrics
universal lipid screening at 9-11 years & again at 17-21