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Flashcards in Hyperlipidemia General Info Deck (12)
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How do we optimize the prevention of heart disease?

Lipid-lowering drugs combined with diet changes and exercise


Main HD risk profiles from a lipid standpoint

-Most cholesterol is carried in LDL particles
-Increased TGs and decreased HDL also a risk factor
-Trans Fat Acids (TFAs)


Components of Hyperlipidemia prevention

-Mediterranean diet has the best data (DON'T advocate for that stupid stupid "low-fat diet")


Historically we have classified lipoprotein abnormalities into what two groups?

1. Increased LDL

2. Combined dyslipidemia: Low HDL, high TG, high non-HDL, and normal LDL


The new approach for LDL targets is NOT based on specific LDL goals. What is the focus?

-Statin trials used specific doses; they didn't titrate to a specific LDL goal

-New focus is on an LDL % reduction

Focus is on more statin use and less use of non-statins


ACC/AHA CVD Risk Calculator purpose

-Determines patients 10-year risk of AMI or CVA based on sex, race, total, and HDL cholesterol, DM, systolic BP, HTN, smoking status



"High Intensity" Statins

-Lower LDL by >50%



Moderate Intensity Statins

-Lower LDL by 30-49%

-Literally all the other statins


The guidelines recommend treating LDL in what patients?

1. Clinical ASCVD
2. DM
3. LDL >190
4. 10-year ASCVD risk >20%
5. 10-year ASCVD risk of 7.5-19.9% in the presence of RF or mild coronary artery calcium


Common causes of secondary hyperlipidemia?

-Obstructive biliary disease
-nephrotic syndrome

-Always rule these out if the initial LDL evaluation is >190


Lipid screening in pediatrics

universal lipid screening at 9-11 years & again at 17-21


Drugs that target LDL

-Cholesterol absorption inhibitors
-bile acid sequestrants
-PCSK9 inhibitors
-ACL inhibitors