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Flashcards in Hyperlipidemia General Info Deck (12)
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1

How do we optimize the prevention of heart disease?

Lipid-lowering drugs combined with diet changes and exercise

2

Main HD risk profiles from a lipid standpoint

-Most cholesterol is carried in LDL particles
-Increased TGs and decreased HDL also a risk factor
-Trans Fat Acids (TFAs)

3

Components of Hyperlipidemia prevention

-Exercise
-Mediterranean diet has the best data (DON'T advocate for that stupid stupid "low-fat diet")

4

Historically we have classified lipoprotein abnormalities into what two groups?

1. Increased LDL

2. Combined dyslipidemia: Low HDL, high TG, high non-HDL, and normal LDL

5

The new approach for LDL targets is NOT based on specific LDL goals. What is the focus?

-Statin trials used specific doses; they didn't titrate to a specific LDL goal

-New focus is on an LDL % reduction

Focus is on more statin use and less use of non-statins

6

ACC/AHA CVD Risk Calculator purpose

-Determines patients 10-year risk of AMI or CVA based on sex, race, total, and HDL cholesterol, DM, systolic BP, HTN, smoking status

-PRIMARY PREVENTION

7

"High Intensity" Statins

-Lower LDL by >50%

-Rosuvastatin
-Atorvastatin***

8

Moderate Intensity Statins

-Lower LDL by 30-49%

-Rosuvastatin
-Atorvastatin
-Literally all the other statins

9

The guidelines recommend treating LDL in what patients?

1. Clinical ASCVD
2. DM
3. LDL >190
4. 10-year ASCVD risk >20%
5. 10-year ASCVD risk of 7.5-19.9% in the presence of RF or mild coronary artery calcium

10

Common causes of secondary hyperlipidemia?

-Meds
-Hypothyroidism
-Obstructive biliary disease
-nephrotic syndrome

-Always rule these out if the initial LDL evaluation is >190

11

Lipid screening in pediatrics

universal lipid screening at 9-11 years & again at 17-21

12

Drugs that target LDL

-Statins
-Cholesterol absorption inhibitors
-bile acid sequestrants
-PCSK9 inhibitors
-ACL inhibitors