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Flashcards in HTN: Other Meds Deck (10)
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1

What are the central a-agonists?

-Clonidine (transdermal)**
-Methyldopa

2

Central a-agonist MOA

-Stimulate a2 in brainstem--> activate inhibitory neuron--> dec sympathetic outflow--> dec PVR, renal vasc resistance, HR, BP

3

Central a-agonist Indications

-HTN
-Caution with anti-HTN and vasodilators

4

Central a-agonist ADRs

-Clonidine (most w PO): dry mouth and sedation, HTN crisis with abrupt withdrawal (1-2 missed doses)--> taper over 1-2 wks**
-Methyldopa: overt sedation, inc prolactin, + Coombs test

5

What are the direct vasodilators?

-Hydralazine
-Minoxidil

6

Direct vasodilators indications

-Hydralazine: HTN, pre-eclampsia/eclampsia, HF in blacks (hydralazine + isosorbide dinitrate)**
-Minoxidil: HTN, alopecia

7

Vasodilator MOA

-Relaxes arterial** SM--> dec PVR--> reflex tachy common

8

Vasodilator Pearls

-Give w b-blocker or centrally acting agent to minimize reflex tachy and inc CO
-Give with diuretic to avoid Na and H2O retention
-Avoid in CAD

9

Vasodilator drug interactions

-Anti-HTN and vasodilators

10

Vasodilator ADRs

-Hydralazine: lupus-like rxn
-Minoxidil: hirsutism, severe fluid retention (add loop), reflex tachy (add b-blocker)