Drug Metabolism Flipped Flashcards Preview

Clinical Pharmacology > Drug Metabolism Flipped > Flashcards

Flashcards in Drug Metabolism Flipped Deck (63)
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1

ADs: fluoxetine, sertraline, duloxetine, paroxetine, bupropion

2D6 inhibitor

2

Amiodarone

inhibits: 1A2, 2C8/9, 2D6, 3A4, Pgp

substrate: 3A4, Pgp

3

Apixaban/rivaroxaban

3A4 substrate

4

Atorvastatin/simvastatin

substrate: 3A4, Pgp

5

Atypical antipsychotics (aripiprazole, risperidone)

substrate: 2D6, 3A4

6

BZDs

substrate: 3A4

7

Carbamazepine

substrate: 3A4

8

Carbamazepine/phenytoin

inducer: 1A2, 2C8/9, 2C19, 3A4, Pgp

substrate: Pgp

9

Carvedilol

substrate: 2C8/9

inhibitor: Pgp

10

CCBs (amlodipine, verapamil, diltiazem)

substrate: 3A4

11

Cimetidine

inhibitor: 1A2, 2C19, 2D6, 3A4

12

Ciprofloxacin

inhibitor: 1A2

13

Citalopram

substrate: 2C19

14

Clarithromycin

substrate: 3A4

inhibitor: 3A4, Pgp

15

Clopidogrel

substrate: 2C19

inhibitor: 2C8/9

16

Codeine

substrate: 2D6

17

Cyclosporine, tacrolimus, siroliumus

substrate: 3A4

18

Dabigatran/rivaroxaban

substrate: Pgp

19

Dexamethasone

inducer: Pgp

20

Digoxin

substrate: Pgp

21

Diltiazem

substrate: Pgp

22

Diltiazem/verapamil

inhibitor: 3A4, Pgp

23

Duloxetine

substrate: 1A2

24

Estrogen

substrate: 3A4, Pgp

inhibitor: 1A2

25

Fluconazole

inhibitor: 2C8/9, 2C19, 3A4

26

Fluoxetine

inhibitor: 2C19

27

Fluoxetine, paroxetine, duloxetine

substrate: 2D6

28

Gemfibrozil

inhibitor: 2C19

29

Gemfibrozil/fenofibrate

inhibitor: 2C8/9

30

Grapefruit Juice

inhibitor: 3A4