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Flashcards in Testable CYP First Exam Deck (47)
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1

Fluoxetine

Substrate of 2D6 --> norfluoxetine
Inhibits 2D6 (strong) and 2C19 (moderate)

2

Paroxetine

Substrate 2D6

3

Sertraline

Inhibits 2D6 (moderate)

4

Citalopram/Escitalopram

Substrate of 2C19 and 3A4

5

Venlafaxine

Substrate of 2D6 and 3A4

6

Desvenlafaxine

None

7

Duloxetine

Substrate of 1A2 and 2D6
Inhibitor of 2D6 (moderate)

8

Bupropion

Inhibitor of 2D6

9

Mirtazapine

Substrate of 1A2, 2D6, 3A4

10

Trazadone

Substrate of 3A4

11

Amitriptyline to nortriptyline via?

2D6

12

Imipramine to desipramine via?

2D6

13

TCAs

Substrate of 2D6 and 2C19

14

Buspirone

Substrate of 3A4

15

BZDs except Lorazepam

Substrate of 3A4 (coadmin with 3A4 inhibitors is CI)

16

1st gen antipsychotics

Substrate of 2D6 +/- 3A4
Mod inhibitor of 2D6

17

Atypicals

Above your paygrade bucko

18

Melatonin receptor agonists

Substrates of 1A2 and 3A4

19

Atomoxetine

Substrate of 2D6 (major)

20

Celecoxib

Substrate of 2C9

21

Codeine --> morphine via?

2D6

22

Hydrocodone --> hydromorphone via?

2D6

23

Oxycodone --> oxymorphone via?

2D6

24

Tramadol --> active metabolite via?

2D6

25

BBW for oxycodone about interactions with? BOLD

3A4 inhibitors

26

Fentanyl

3A4 major

27

Hydrocodone and oxycodone

3A4 (major) and 2D6 (minor)

28

Tramadol (prodrug)

3A4 and 2D6 (major)

29

Codeine (prodrug)

2D6 (major)

30

NO CYP metab with opioids

Morphine, Hydromorphone, Oxymorphone