Flashcards in Opioid Drug Interactions Deck (12)
-Well absorbed from SQ, IM, transdermal, and mucosal surfaces
-Most have extensive 1st pass metabolism
-Low bioavailability overall
-delay gastric emptying & absorption of many orally administered drugs (especially platelet inhibitors)
***All of these are contraindicated with Clarithromycin
CYP2D6 Substrates (Major)
-Potent CYP2D6 inhibitors will prevent these drugs from being converted
-Ultra-rapid metabolizers may have issues with OD
Opioids with essentially no CYP interaction
**more predictable in patients with CYP2D6 polymorphisms
-analgesia, euphoria, respiratory depression, physical dependence properties
Opioid additive interactions
-Additive analgesia with APAP/NSAIDs --> GOOD!
-Increased sedation with other sedatives/hypnotics --> BAD!
All Opioids have a black box warning regarding what class of drugs?
Which drug class is contraindicated with or within 14 days of using an opioid?
****All products contraindicated
What two opioids put patients at risk for serotonin syndrome when combined with other serotonergic drugs?
What is a common result of mixing opioids and anticholinergic drugs?