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Flashcards in HTN: CCB Deck (11)
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1

What are the DHP CCBs?

-Short acting: nifedipine**
-Longer acting: felodipine, isradipine, nicardipine, nisoldipine
-Long acting: Amlodipine**

2

What are the non-DHP CCBs?

-Verapamil
-Diltiazem**

3

DHP MOA

-Vasodilation by preferentially altering vascular smooth muscle--> dec PVR--> inc sympathetic tone--> blunts (-) ionotropic effect of DHP
-Little to no neg effect on cardiac contractility or conduction

4

Non-DHP MOA

-Preferentially effects cardiac contractility and conduction--> neg ionotropic effect (verapamil > diltiazem)
-Less potent vasodilator

5

Indications

-DHP: HTN, angina, Raynaud's
-Non-DHP: Arrhythmias (SVT, a-fib), verapamil used for cluster HA prophy**

6

Non-DHP Precautions/CI

-2nd or 3rd degree AV block
-SSS (unless pacemaker)
-Brady <50 bpm
-HF
-B-blockers and digoxin (conduction issues)**
-Anti-HTN and vasodilators (DHP and non-DHP)

7

3A4 substrates

-Nifedipine, amlodipine, diltiazem
-Clarithro-amlodipine ass w hypoTN, edema, brady, AKI

8

3A4 inhibitors

Non-DHP CCB (verapamil/diltiazem)

9

DHP ADRs

-Less likely w long acting agents
-HA, dizziness, flushing
-Peripheral edema, reflex tachy**
-Dyspepsia
-Special ADR: gingival hyperplasia (nifedipine >amlodipine)

10

Non-DHP ADRs

-HA, dizziness, flushing, peripheral edema
-Special: verapamil (constipation)**

11

CCB general MOA

Inhibit L-type Ca channel