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Clinical Pharmacology > Depression/Anxiety > Flashcards

Flashcards in Depression/Anxiety Deck (42)
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1

If you have a patient that struggles with depression and anorexia, what drug should be considered?

Mirtazapine (increased appetite)

2

Which SSRI has strict dosing?

Citalopram (should no exceed 40mg/d for anyone, should not exceed 20mg/d for most pts >60yo or those on CYP2C19 inhibitors)

Higher doses = increased risk of QT

3

CI of Bupropion

Pts with seizure history

4

T/F: orthostasis is common with tertiary and secondary amine TCAs

True

5

What is FINISH syndrome? What drug is it worse with?

Flu-like symptoms
Insomnia
Imbalance
Sensory disturbances
Hyperarousal

Paroxetine

6

Which SNRI should you not use for pts with liver disease due to hepatotoxicity risk?

Duloxetine

7

If a pt presents with atypical MDD with hyperphagia or hypersomnia, what class of meds should be considered?

Monoamine Oxidase A Inhibitors

8

Which SNRI is most associated with dose dependent HR/BP increase?

Venlafaxine

9

Which TCA should be considered for migraine prophylaxis?

Amitriptyline

10

Which SSRI has a long half life?

Fluoxetine

11

Which BZD is good for seizure disorders?

Clonazepam

12

Priapism = what AD?

Trazadone

13

What meds are short term/intermittent use for anxiety?

Benzo's

14

What are the SNRIs? (4)

Venlafaxine
Desvenlafaxine
Duloxetine
Milnacipran/Levomilnacipran

15

Which 3 benzo's come in IV formulation?

Lorazepam
Diazepam
Midazolam

16

What medication is usually the drug of choice for anxiety?

SSRI/SNRI (venlafaxine)

17

If your patient is trying to quit smoking and has depression, what should you use?

Bupropion

18

What is the monoamine oxidase B inhibitor? Pts with what neurologic condition may benefit due to the patch formulation?

Selegiline

Parkinson's pts who cannot swallow

19

What are the 2 secondary amine TCAs?

Desipramine
Nortriptyline

20

Which SSRI has a very short half life and concerns for withdrawal?

Paroxetine

21

Which SNRI is best for pain from diabetic peripheral neuropathy/fibromyalgia/chronic MSK pain?

Duloxetine

22

When should a TCA be considered?

Intolerant or refractory to SSRI/SNRI, or for pain syndromes

23

Which SSRI is best for kids?

Fluoxetine

24

Which amines have more sedation, wt gain, and anticholinergic effects?

Tertiary > secondary

25

What AD is safe for pregnancy?

Sertraline

26

What BZD is used for status epilepticus?

Lorazepam

27

What are the 5 BZD's?

Alprazolam
Clonazepam
Lorazepam
Diazepam
Midazolam

28

What are the 4 tertiary amine TCAs?

Imipramine, Clomipramine, Doxepin, and Amitriptyline

29

What are the 3 Monoamine Oxidase A Inhibitors?

Isocarboxazid
Tranylcypromine
Phenelzine

30

Which two drugs are SSRIs and partial 5-HT receptor agonists?

Vilazodone
Vortioxetine