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Flashcards in Pharmacology Deck (192)
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1

Enzyme kinetics that follow a sigmoidal curve follow what type of kinetics?

Cooperative kinetics

2

On a Lineweaver-Burk plot, what point is on the X-axis less than zero?

-1/K_M

3

On a Lineweaver-Burk plot, what point is on the Y-axis

1/V

4

On a Lineweaver-Burk plot, what is the Y-intercept?

1/Vmax

5

On a Lineweaver-Burk plot, what equation represents the slope?

Km/Vmax

6

Which type of inhibitors intercept the Y-axis with the natural agonist?

competitive

7

Which type of inhibitors do not intercept the Y-axis with the natural agonist?

noncompetitive

8

How many half lives does it take to reach 90% of steady state concentration?

3.3

9

Failure of what three organs can lead to decreased drug clearance?

heart, liver, kidneys

10

What is the equation for maintenance dose?

(desired concentration)(clearance)(interval)/F

11

What is zero order elimination?

clearance is constant regardless of drug concentration

12

What class of drugs are weak bases?

amphetamines

13

What drug is given to treat an amphetamine OD?

ammonium chloride

14

What three modifications are made during Phase I drug metabolism?

oxidation, reduction, hydrolysis

15

Do the CYP enzymes function during Phase I or Phase II clearance?

phase I

16

Do elderly patiets lose phase I or Phase II metabolism first?

Phase I

17

What three modifications are done during Phase II metabolism?

Glucoronidation, Acetylation, Sulfation

18

Are drugs still often active after Phase I metabolism? Phase II?

Phase I = yes

Phase II = no

19

What is the equation for therapeutic index?

TD50/ED50

20

Where are most D2 receptors found?

brain

21

Where are H1 receptors located?

nasal and bronchi

22

What do H1 receptors do to the bronchioles?

increase contraction

23

Where are the V1 receptors? What is their action?

smooth muscle

contraction

24

What class of drug blocks choline entry into the nerve terminal? What ion is used for this transport?

hemicholiniums

sodium

25

What drug blocks acetylcholine transport into the vesicle? What ion?

vesamicol

H+

26

What class of drug prevents vesicular discharge of acetylcholine?

Botulinum

27

What drug blocks Tyrosine Hydroxylase? What is the normal product of this enzyme?

Metyrosine

DOPA

28

What drug blocks the incorporation of dopamine into adrenergic vesicles?

reserpine

29

What are the two drugs that block adrenergic vesicular fusion with the presynaptic cell membrane?

bretylium

Guanethidine

30

What hormone can increase norepinephrine discharge from adrenergic nerve terminals?

AT II