Flashcards in Pharmacology Deck (192)
Enzyme kinetics that follow a sigmoidal curve follow what type of kinetics?
On a Lineweaver-Burk plot, what point is on the X-axis less than zero?
On a Lineweaver-Burk plot, what point is on the Y-axis
On a Lineweaver-Burk plot, what is the Y-intercept?
On a Lineweaver-Burk plot, what equation represents the slope?
Which type of inhibitors intercept the Y-axis with the natural agonist?
Which type of inhibitors do not intercept the Y-axis with the natural agonist?
How many half lives does it take to reach 90% of steady state concentration?
Failure of what three organs can lead to decreased drug clearance?
heart, liver, kidneys
What is the equation for maintenance dose?
What is zero order elimination?
clearance is constant regardless of drug concentration
What class of drugs are weak bases?
What drug is given to treat an amphetamine OD?
What three modifications are made during Phase I drug metabolism?
oxidation, reduction, hydrolysis
Do the CYP enzymes function during Phase I or Phase II clearance?
Do elderly patiets lose phase I or Phase II metabolism first?
What three modifications are done during Phase II metabolism?
Glucoronidation, Acetylation, Sulfation
Are drugs still often active after Phase I metabolism? Phase II?
Phase I = yes
Phase II = no
What is the equation for therapeutic index?
Where are most D2 receptors found?
Where are H1 receptors located?
nasal and bronchi
What do H1 receptors do to the bronchioles?
Where are the V1 receptors? What is their action?
What class of drug blocks choline entry into the nerve terminal? What ion is used for this transport?
What drug blocks acetylcholine transport into the vesicle? What ion?
What class of drug prevents vesicular discharge of acetylcholine?
What drug blocks Tyrosine Hydroxylase? What is the normal product of this enzyme?
What drug blocks the incorporation of dopamine into adrenergic vesicles?
What are the two drugs that block adrenergic vesicular fusion with the presynaptic cell membrane?