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Flashcards in Pathology Deck (174)
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1

What does apoptosis use for an energy source?

ATP

2

Is DNA laddering sensitive or specific for apoptosis?

sensitive

3

What type of chromosome damage does radiation produce?

dsDNA

4

Is the intrinsic or extrinsic pathway of apoptosis used during embryogenesis?

intrinsic

5

What are the two pro-apoptosis proteins?

BAX and BAK

6

Which protein does Bcl-2 inhibit?

Apaf-1

7

What is the fuction of Apaf-1?

induce caspases

8

Which CD molecule is the Fas ligand?

CD95

9

What are the two pro-apoptotic molecules released by Tcells?

perforin and granzyme B

10

Which molecule mediates thymic medullary negative selection?

Fas Ligand

11

Which bacteria can produce caseous necrosis?

Nocardia

12

How does calcium appear during fat necrosis?

dark blue

13

What type of necrosis take place during HSP and Churg-Strauss?

fibrinoid

14

What type of necrosis takes place during malignant HTN?

fibrinoid

15

Damage to what organ often triggers irreversible apoptosis?

mitochondria

16

What type of immune reaction takes place in response to a foreign body?

granuloma

17

Granulomas are often surrounded by a ring of what type of immune cell?

lymphocytes

18

An excess of what type of tissue is found in Keloids?

granulation

19

What two specific types of cells in the brain are most susceptible to ischemia?

pyramidal or Hippocampus

Purkinje of cerebellum

20

What is the name for the skin lesion produced by pseudomonas?

Ecthyema gangrenosum

21

What does ecythema gangrenosum look like?

black and necrotic

22

Pseudomonas can infect people with what specific immune cell deficiency?

neutropenia

23

Which selectin is on endothelial cells?

E and P

24

Which selectin is on neutrophils?

L-selectin

25

Which cells express ICAM-1?

endothellial

26

What are the four names for the protein that binds ICAM-1?

CD18

β2-integrin

LFA1

MAC1

27

Which protein mediates transmigration through the endothelial cells?

PECAM-1

28

Chromatolysis is involved after injury to what structure?

axon

29

What three reactions take place during chromatolysis?

cellular swelling

displacement of nucleus

dispersion of Nissl

30

Does dystrophic calcification take place during normocalcemia or hypercalcemia?

normo