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Flashcards in Heme and Onc. Deck (501)
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1

What cell type contains dense granules? What are the two products of dense granules?

erythrocytes

ADP and calcium

2

What type of cell contains αgranules? What are the two products of αgranules?

erythrocytes

vWF and fibrinogen

3

In what organ is approximately 1/3 of platelet pool stored?

spleen

4

What is the vWF receptor?

GpIb

5

What is the fibrinogen receptor?

GpIIb/GpIIIa

6

What four enzymes are contained by neutrophils?

ALP
collagenase
lysozyme
lactoferrin

7

Do macrophages function via MHC II or MHC I?

MHC II

8

What type of nucleus do eosinophils possess?

bilobed

9

What two enzymes are produced by eosinophils granules?

histaminase and arylsulfatase

10

What are the three components of basophil granules?

histamine, heparin and leukotrienes

11

What form of leukemia can isolated basophilia be indicative of?

CML

12

What granulocyte binds Fc of IgE?

mast cell

13

What drug prevents mast cell degranulation?

cromolyn sodium

14

What two receptors do dendritic cells express?

Fc and MHC II

15

What are dendritic cells in the skin called?

Langerhans cells

16

What two CD molecules are expressed by B-lymphocytes?

19 and 20

17

What is the CD molecule required for T-cell activation?

CD28

18

Multiple myeloma is a cancer of what cell type?

plasma cells

19

If a person has type A blood, What antigen do they express on RBCs? What antibody is circulating?

A = RBC

Anti-B = circulating

20

If a person has type B blood, What antigen do they express on RBCs? What antibody is circulating?

B = RBC

anti-A = circulating

21

What type of immunoglobulin targets RBC antigens?

IgM

22

anti-Rh is what type of antibody?

IgG

23

If a person has type AB blood, What antigen do they express on RBCs? What antibody is circulating?

A and B = RBC

no circulating antibodies

24

What can people with AB blood universally donate?

plasma

25

What can people with AB blood universally receive?

blood

26

If a person has type O blood, What antigen do they express on RBCs? What antibody is circulating?

no antigen on RBCs

antigens to A and B in plasma

27

What can people with O blood universally donate?

blood

28

What can people with type O blood universally accept?

plasma

29

What three coagulation factors can thrombin activate?

V and VIII and thirteen

30

What coagulation factors activate factor X?

VIIa and VIIIa