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Flashcards in Immunology Deck (324)
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1

What part of a lymph node would enlarge during a viral infection?

Paracortex

2

What cell is found in the PALS of the white pulp of the spleen?

Tcells

3

What happens in the marginal zone?

where APCs present blood borne antigen

4

What immunoglobulin is decreased post-splenectomy?

IgM

5

Which two additonal bacteria are encapsulated and arent in your mnemonic?

E. coli

GBS

6

Which pharyngeal pouch does the thymus develop from?

3rd

7

What type of Tcells are in the cortex?

Immature T cells

8

What type of Tcells are in the medulla?

mature T cells

9

What type of viral nucleic acid do innate immune cells respond to?

ssRNA

10

Which HLA loci correspond to MHC One?

A/B/C

11

Which HLA loci correspond to MHC Two?

DP/DQ/DR

12

What MHC event activates NK Cells?

loss of MHC One

13

In what organelle is antigen loaded onto MHC One? Via what protein?

rER

TAP transporter

14

In what organelle is antigen loaded onto MHC Two?

acidified endosome

15

Which HLA-Haplotype is associated with hemochromatosis?

HLA-A3

16

What condition is associated with HLA-B27?

PAIR

17

What HLA haplotype is associated with Pernicious anemia?

HLA-DR5

18

Which HLA haplotype is associated with Graves?

DR3

19

Which four cytokines activate NK cells?

IL2

IL12

IFN-α

IFN-β

20

Which CD molecule on NK cells mediates ADCC?

CD16

21

What is the function of CD16?

binds Fc of IgG

22

Where does positive Tcell selection occur?

cortex

23

Where does negative Tcell selection occur?

medulla

24

What is positive selection?

Capable of interacting with MHC

25

What is negative selection?

removes cells that bind MHC too much

26

Which CD molecules does an immature Tcell express?

CD4 and CD8

27

Which interleukin induces a TH1 response?

IL-12

28

Which interleukin induces a TH2 response?

IL-4

29

Which two cytokines induce a TH17 cell?

TGF-β

IL-6

30

What the the costimulatory molecules for Tcells?

B7 and CD28