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Flashcards in Neurology Deck (523)
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1

What is the MOA of ethosuximide?

blocks T-type Ca2+ channels

2

What is the MOA of carbamazepine?

Na+ channel blocker

3

What is the MOA of valproic acid?

Na+ channel blocker

inhibit GABA transaminase

4

What is the MOA of gabapentin?

blocks Ca2+ channels

GABA analogue

5

What is the MOA of Topiramate?

Na+ channel blocker

6

What are the MOAs of tigabine?

inhibits GABA transaminase

inhibit GABA reuptake

7

What is the function of the notochord?

induce ectoderm to differentiate into neuroectoderm

8

What two things does the neural plate give rise to?

neural crest cells

neural tube

9

Is the alar plate dorsal or ventral?

dorsal

10

Is the alar plate motor or sensory?

sensory

11

Is the basal plate dorsal or ventral?

ventral

12

Is the basal plate motor or sensory?

motor

13

What two structures does the prosencephalon give rise to?

telencephalon and diencephalon

14

What two structures does the telencephalon give rise to in adults?

cerebral hemispheres

lateral ventricles

15

What two structures does the diencephalon give rise to in adults?

thalamus

3rd ventricle

16

What two structures does the mesencephalon give rise to in adults?

midbrain


cerebral aqueduct of sylvius

17

What two structures does the rhomboencephalon give rise to?

Metencephalon

Myelencephalin

18

What three structures does the Metencephalon give rise to?

pons

cerebellum

upper part of 4th ventricle

19

What two structures does the Myelencephalon give rise to?

medulla

lower part of 4th ventricle

20

Which epithelial layer gives rise to microglia?

mesoderm

21

During what week of development would the neuropores fail to close during a neural tube defect?

4th week

22

What enzyme can be elevated during a neural tube defect?

AchE

23

Maternal Diabetes is associated with what neural development defect?

anencephaly

24

What specific structure is defective during Anencephaly?

anterior neural tube

25

What lab value would be affected by Anencephaly?

increased AFP

26

What would be noticeable during pregnancy regarding anencephaly? Why?

polyhydramnios

swallowing center

27

What signaling pathway may be implicated during Holoprosencephaly?

sonic hedgehog

28

What two structures herniate during a Chiari Type II?

cerebellar tonsils and vermis

29

What other pathology is Chiari Type Two associated with? Causing?

lumbar myelomeningocele

paralysis below defect

30

Which specific structure undergoes agenesis during Dandy-Walker?

cerebellar vermis