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Flashcards in Antimicrobrials Deck (216)
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1

What are the two toxicities of penicillins?

hypersensitivity and hemolytic anemia

2

Which has a greater oral bioavailability, ampicillin or amoxicillin?

amoxicillin

3

What six bugs can be treated with ampicillin/amoxicillin?

H. flu

E. coli

Listeria

Proteus

Salmonella

Shigella

4

What would be the most severe reaction of ampicillin/amoxicillin?

pseudomembrane colitis

5

What are the three penicillinase-resistant lactams?

Naficillin

Dicloxacillin

Oxacillin

6

Are the penicillinase-resistant lactams used to treat MRSA?

no

7

What are the two beta-lactim anti-pseudomonals?

Piperacillin and Ticeracillin

8

What other drug are Piperacillin and Ticeracillin administered with?

beta-lactamase inhibitors

9

What are the three β-lactamase inhibitors?

Sulbactam

Tazobactam

Clavulanic acid

10

Which cephalosporin can cover MRSA?

Ceftaroline

11

Which four bacteria are not covered by cephalosporins?

Listeria

Atypicals

MRSA

Enterococci

12

What are the two first generation cephalosporins?

Cefalexin and Cefazolin

13

What three bugs are the first generation cephalosporins effective against?

Proteus

E. coli

Klebsiella

14

What are the three 2nd generation cephalosporins?

Cefaclor

Cefoxitin

cefuroxime

15

What are the bugs treated by 2nd generation cephalosporins?

H. flu

Enterobacter

Klebsiella

Proteus

E. coli

Klebsiella

Serratia

16

What two bugs does Ceftriaxone treat?

meningitis and gonorrhea

17

What are the two cephalosporins for Pseudomonas?

Ceftazidime

Cefepime

18

What is the fourth generatuon cephalosporin?

Cefepime

19

What is cefepime active against?

Pseudomonas

20

What is the 5th generation cephalosporin?

Ceftoraline

21

What is ceftoraline not active against?

Pseudomonas

22

Which class of drugs would display nephrotoxicity upon co-administration with cephalosporins?

Aminoglycosides

23

Which β-lactam class of drugs can cause a Vitamin K deficiency?

Cephalosporins

24

What is the MOA of Aztreonam?

penicillin binding protein

25

What class of drugs is Aztreonam synergistic with?

Aminoglycoside

26

What type of bacteria does aztreonam display activity against?

gram-negative rods ONLY

27

What other drug are piperacillin and tazobactam used with?

β-lactam inhibitors

28

What is the most important side effect of Carbapenems?

seizure

29

What is the MOA of carbapenems?

β-lactam

30

What enzyme can inactivate carbapenems?

Dehydropeptidase