Flashcards in Biochemistry Deck (372)
What two amino acids are histones rich in?
lysine and arginine
What type of islands does DNA become methylated at?
What DNA base has a methyl group?
Uracil is a deaminated form of what base?
What three amino acids are necessary for purine synthesis?
Glycine, Aspartate and Glutamine (GAG)
S in Nucleoside = ?
base + Sugar
T in Nucleotide = ?
base + phosphaTe
What amino acid does pyrimidine biosynthesis begin with? What enzyme acts on it?
What amino acid joins orotic acid? What drug inhibits this rxn?
What enzyme does Leflunomide inhibit?
What enzyme does hydroxyurea inhibit?
What enzyme does 5-FU inhibit? What end-product has an inhibition of production?
IMP Dehydrogenase is involved in the RLS of what nucleotide?
What enzyme does 6-MP inhibit? What is the pro-drug of 6-MP?
What product are all purines synthesized from? What enzyme works on this product?
What is the prodrug of 6-MP?
What three drugs inhibit dihydrofolate reductase?
Trimethoprim, Methotrexate and Pyrimethamine
What rxn does dihydrofolate reductase catalyze?
DHF to THF
What rxn does ADA catalyze?
deamination of adenosine into inosine
What is the co-factor for HGPRTase?
What two rxns does xanthine oxidase catalyze?
1. hypoxanthine to xanthine
2. xanthine to uric acid
What enzyme becomes inhibited during ADA Deficiency?
Under the action of HGPRTase, what is hypoxanthine converted into?
Under the action of HGPRTase, what is guanine converted into?
What codon codes for methionine?
What codon codes for tryptophan?
What are the only two amino acids coded for by a single codon?
methionine and tryptophan
What drug inhibits prokaryotic Topoisomerase Type II?
What two DNA polymerases are unique to prokaryotes?
Type III and Type I