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Flashcards in Biochemistry Deck (372)
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1

What two amino acids are histones rich in?

lysine and arginine

2

What type of islands does DNA become methylated at?

CpG

3

What DNA base has a methyl group?

thymine

4

Uracil is a deaminated form of what base?

cytosine

5

What three amino acids are necessary for purine synthesis?

Glycine, Aspartate and Glutamine (GAG)

6

S in Nucleoside = ?

base + Sugar

7

T in Nucleotide = ?

base + phosphaTe

8

What amino acid does pyrimidine biosynthesis begin with? What enzyme acts on it?

Glutamine

CPS Two

9

What amino acid joins orotic acid? What drug inhibits this rxn?

aspartate

Leflunomide

10

What enzyme does Leflunomide inhibit?

dihydroorotate Dehydrogenase

11

What enzyme does hydroxyurea inhibit?

Ribonucleotide Reductase

12

What enzyme does 5-FU inhibit? What end-product has an inhibition of production?

thymidylate synthase

dTMP

13

IMP Dehydrogenase is involved in the RLS of what nucleotide?

GTP

14

What enzyme does 6-MP inhibit? What is the pro-drug of 6-MP?

HGPRTase

azathioprine

15

What product are all purines synthesized from? What enzyme works on this product?

Ribose-5-Phosphate

PRPP Synthetase

16

What is the prodrug of 6-MP?

azathioprine

17

What three drugs inhibit dihydrofolate reductase?

Trimethoprim, Methotrexate and Pyrimethamine

18

What rxn does dihydrofolate reductase catalyze?

DHF to THF

19

What rxn does ADA catalyze?

deamination of adenosine into inosine

20

What is the co-factor for HGPRTase?

PRPP

21

What two rxns does xanthine oxidase catalyze?

1. hypoxanthine to xanthine

2. xanthine to uric acid

22

What enzyme becomes inhibited during ADA Deficiency?

ribonucleotide reductase

23

Under the action of HGPRTase, what is hypoxanthine converted into?

IMP

24

Under the action of HGPRTase, what is guanine converted into?

GMP

25

What codon codes for methionine?

AUG

26

What codon codes for tryptophan?

UGG

27

What are the only two amino acids coded for by a single codon?

methionine and tryptophan

28

What drug inhibits prokaryotic Topoisomerase Type II?

fluoroquinolones

29

What two DNA polymerases are unique to prokaryotes?

Type III and Type I

30

In which direction does DNA pol III add nucleotides?

5' to 3'