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Flashcards in Endocrine Deck (254)
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211

What is the most common cause of death in acromegaly?

heart failure

212

Familial Hypocalciuric Hypercalcemia features a defective receptor for what?

Calcium sensor

213

Which diuretic can block lithium uptake?

Amiloride

214

What is the cause of Familial Primary Hypoparathyroidism?

constant activating of calcium receptor

215

What is the pathogenesis of Pseudohypoparathyroidism?

unresponsiveness of kidney to PTH

216

How do calcimimmetics function? What is the Calcimimmetic?

increase responsiveness of Calcium sensor

Cincalacet

217

What two symptoms can calcitonin produce during Medullary Carcinoma of Thyroid?

flusing and diarrhea

218

Do neoplastic thyroid cells produce hormone?

no

219

What are two causes of low ALP?

Hypothyroidism

Pernicious anemia

220

Which two drugs compete with Na/I for uptake?

perchlorate

pertechtenate

221

What is the mechanism by why beta-blockers can treat hyperthyroidism?

decreases peripheral conversion of T4 to T3

222

Other than thyroid hormone, which two hormones may increase during Thyroid Storm?

ALP and Catecholamines

223

What causes the increased ALP during Thyroid Storm?

bone turnover

224

What are the Four IgG4 Related Diseases?

Riedel Thyroiditis

Autoimmune pancreatitis

Retroperitoneal fibrosis

non-infectious Arthritis

225

What is the name of Hypothyroid Myopathy? What lab will be seen?

Hoffman Syndrome

increased creatine kinase

226

Hurthle Cells are associated with what disease?

Hashimoto

227

What are Cretinism kids short?

thyroid hormone is required for GH release

228

GH works synergistically with what other hormone?

TSH

229

Is sodium increased or normal during Conn Syndrome? Why?

normal

aldosterone escape = increased ANP

230

What enzyme is inhibited by Tetyrapone?

11-beta-Hydroxylase

231

Would Cushings Disease result in adrenal cortical hyperplasia or hypertrophy?

hyperplasia

232

Which two types of hormones use Intrinsic Tyrosine Kinase?

Insulin and Growth Factors

233

What is the 2nd messenger of Intrinsic Tyrosine Kinase?

MAP Kinase

234

Which three hormones use Receptor Associated Tyrosine Kinases?

Prolactin

Growth Hormone

Cytokines

235

What is the 2nd messenger of Receptor Associated Tyrosine Kinases?

JAK/STAT

236

Which two drugs can deplete magnesium?

aminoglycosides and diuretics

237

Which social factor can deplete calcium?

alcohol

238

Which precursor does the sun work on in the synthesis of vitamin D?

7-dehydrocholesterol

239

Which precursor does the sun work on in the synthesis of vitamin D?

7-dehydrocholesterol

240

What two reactions does Anastrozole inhibit?

Androstenedione into Estrone

Testosterone into Estradiol