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Flashcards in Endocrine Deck (254)
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181

What are the toxicities of first generation sulfonylureas?

Disulfarim like reaction

hypoglycemia in pt's with renal failure

182

What are the three second generations sulfonylureas? Main toxicity?

Glipizide/Glyburide/Glimeperide

hypogycemia

183

What is the MOA of -litazones?

increase PPAR txn to increase insulin receptor density

184

What are the four toxicities of the litazones?

edema

weight gain

hepatotoxicity

HF

185

What are the two α-glucosidase Inhibitors?

Miglitol

Acarbose

186

What are the two functions of Amylin?

decreases gastric emptying

inhibit glucagon release

187

What drug is the Amylin analogue? Main toxicity?

Pramlintide

hypoglycemia

188

What are the two MOAs of GLP1?

increase insulin

decrease glucagon

189

What are the GLP1 analogues?

Liraglutide

Exenatide

190

What are the two MOAs of DPP-4 Inhibitors?

increase insulin

decrease glucagon

191

What is the common suffix for DPP-4 Inhibitors?

-gliptin

192

What drug is used to treat hyperthyroidism during pregnancy?

Propylthiouracil

193

Which anti-thyroid can hepatotoxicity?

Propylthiouracil

194

What drug can be used during Turner Syndrome?

GH

195

What drug control uterine hemorrhage?

Oxytocin

196

What is the MOA of demeclocycline?

ADH antagonist

197

Treat Iatrogenic Cushings Osteoporosis with what drug?

bisphosphonates

198

Is fludricortisone a more powerful glucocorticoid or mineralocorticoid?

mineralocorticoid

199

The Meglitinides have a similar MOA to what diabetic drug?

sulfonylureas

200

Which metabolite can build up during metformin therapy causing lactic acidosis? Why?

lactate

cant be shunted to GNG

201

What are the two toxicities of DPP4 Inhibitors?

urinary and respiratory infections

202

What are the three toxicities of GLP1 analogues?

nausea

vomiting

pancreatitis

203

What gene is effected during MDOY?

glucokinase

204

What are the four D's of a Glucoganoma?

Dermatitis

Diabetes

DVT

Depression

205

In what cells is Leptin produced?

adipocytes

206

What neurotransmitter does Leptin suppress the secretion of?

Neuropeptide Y

207

What are the two characteristics of a Lipid Panel of a Diabetic?

High triglycerides

low HDL

208

There is an insensitivity to what hormone during Laron Syndrome?

GH

209

What is the first line Tx for gestational diabetes? Second?

Insulin

Glyburide

210

What three drugs, other than lithium, can cause Nephrogenic Diabetes Insipidus?

Conivaptan

Tolvaptan

Demeclycycline