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Flashcards in Endocrine Deck (254)
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31

What does hyperthyroidism do to warfarin levels?

increase warfarin levels

32

What does prolactin do to GnRH levels?

inhibit GnRH synthesis

33

Which hypothalamic hormone increases prolactin levels?

TRH

34

What type of drugs can be used to treat a prolactinoma?

dopamine agonists

35

What does prolactin do to dopamine synthesis?

increase

36

Which cytokine does GH mediate its effects through?

IGF1

37

Does GH increase or decrease insulin resistance?

increase insulin resistance

38

What does glucose do to GH release?

decrease

39

Which nuclei synthesizes ADH?

Supra-optic

40

Which ADH receptor isoform mediates fluid volume?

V2

41

Which ADH receptor isoform mediates blood pressure?

V1

42

What drug inhibits desmolase?

Ketoconazole

43

What can androstenedione be metabolized into? What enzyme?

Estrone

Aromatase

44

How can 21α-Hydroxylase Deficiency be differentiated from 17α-Hydroxylase Deficiency?

17α-Hydroxylase Deficiency would present with hypertension

45

Would 17α-Hydroxylase Deficiency present with low or high renin?

low

46

What hormone causes the hyperplasia during CAH?

ACTH

47

Which adrenergic receptor does cortisol increase the synthesis of?

α1

48

Why does excess cortisol cause abdominal striae?

cortisol decreases fibroblast activity

49

What does cortisol do to circulating neutrophil levels? Why?

neutrophilia

decrease adhesion

50

What does cortisol do to mast cells?

blocks histamine release

51

What does cortisol do to eosinophils?

induces apoptosis

52

Which interleukin does cortisol block?

IL2

53

Why does cortisol cause osteoporosis?

blocks osteoblast activity

54

Which ions does PTH increase the resorption of out of bone?

calcium and phosphate

55

Where in the kidney does PTH promote the reabsorption of calcium?

DCT

56

Where in the kidney does PTH promote the excretion of phosphate?

PCT

57

What cytokine does PTH up-regulate the synthesis of?

RANK-L

58

Does RANK-L bind to osteoblasts or osteoclasts?

osteoblasts

59

What does mildly decreased Magesium do to PTH levels?

increase PTH

60

What does markedly decreased Magesium do to PTH levels?

decrease PTH