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Flashcards in Biochemistry Deck (372)
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61

What ribosomes make up the eukaryotic ribosome?

40S and 60S

62

What ribosomes make up the prokaryotic ribosome?

30S and 50S

63

What is the energy source for the intitiation of protein synthesis?

GTP

64

What does the A site of the ribosome hold?

A-mino acyl tRNA

65

What amino acid charged tRNA does not bind to the A site?

methionine

66

What is the function of rRNA?

catalyze peptide bond

67

What does 'A' of APE stand for according to translation?

accodomates incoming amino-acyl tRNA

68

What does 'P' of APE stand for according to translation?

acomodates growing Peptide

69

What does 'E' of APE stand for according to translation?

holds Empty tRNA

70

What are the three stop codons?

UAG, UAA, UGA

71

What are the two stable (quiescent) cell types?

hepatocytes and lymphocytes

72

What organelle do Nissl bodies function as?

rER

73

What cell type are Nissl bodies found in?

Neurons

74

What two activities occur at the smooth ER?

steroid synthesis

drug detoxification

75

N-linked glycosylation occurs on what amino acid?

asparagine

76

O-linked glycosylation occurs on what amino acid?

serine and threonine

77

What monosaccharide is added to proteins for them to be trafficked to what organelle?

mannose-6-phosphate

lysosomes

78

What is defective in I-cell disease? Which organelle is responsible for the error?

phosphorylation of mannose residues

golgi

79

Does COP-I traffic anterograde or retrograde?

retrograde

80

Does COP-II traffic anterograde or retrograde?

anterograde

81

What two types of fatty acids are processed in the peroxisome?

very long chain and branched chain

82

What heterodimer makes up microtubules? What molecule do microtubules use for energy?

α-tubulin and β-tubulin

GTP

83

What three structures possess microtubules?

flagella, cilia and mitotic spindles

84

What five drugs act on microtubules?

Mebendazole,Griseofulvin, Colchicine, Vincristine/Vinblastine, Paclitaxel

85

What is the mnenomic for the five drugs that act on microtubules?

Microtubules Get Constructed Very Poorly

86

Is dynein retrograde or anterograde?

retrograde

87

Is kinesis retrograde or anterograde?

anterograde

88

Do cilic have a 9+2 or a 9+3 arrangement?

9+2

89

What structure is defective in kartagener syndrome? What specific protein?

cilia

dynein

90

What is the main manifestation of Kartagener syndrome in men and women?

infertility