Chapter 27 Bone, Cartilage, and Soft Tissue Sarcomas PP Flashcards Preview

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Flashcards in Chapter 27 Bone, Cartilage, and Soft Tissue Sarcomas PP Deck (42)
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1

Most sarcomas, especially high-grades ones metastasize _______ to the _____

hematologically

lung

2

____ tumors displace soft tissue; intact cortex with sclerotic margins

benign

3

_____ tumors cause soft tissue swelling and bone erosion with poorly defined margins;neoplasm extends into surrounding tissue; single lesions can be imaged on plain radiographs;Bone scans or PET can detect silent lesions;CT,MRI precisely define location of bone tumor and extensions; surgical biopsy

malignant

4

Primary bone tumors are rare but most often found in _____ &_______

distal femur and proximal tibia

5

Most common types of malignant bone tumors are _______ bone tumors

metastatic

6

____ & ____ are most common metastatic sites.

Spine and pelvis

7

______ is used to treat bone mets from prostate cancer

Strontium-89

8

Common primary sites that spread to bone include:

Prostate, breast, lung (most common), kidney, and thyroid

9

Most common malignant primary bone tumor in children, peaks in teen years. 2nd most common in adults

osteosarcoma

10

osteosarcomas most often occur where?

give three examples

at the end of long bones

Distal femur
Proximal tibia
Proximal humerus

11

what is the treatment choice for osteosarcoma

surgery and chemo therapy

12

is osteosarcoma radiosensitive or radioresisitant?

radioresistant

13

does osteosarcomas consist of osteoblastic or osteolytic lessions?

osteoblastic

14

Approx. 85% of osteosarcomas are grade __ or __ at diagnosis

3 or 4

15

what is an unfavorable prognostic sign of osteosarcoma

pulmonary mets

16

what is a chondrosarcoma?

malignant tumor of cartilage

17

Chondrosarcoma is the most common primary bone tumor in ____

adults

18

Chondrosarcoma commonly occurs in what type of bone? give two examples

long bones

femur as well as the pelvis

19

what is the primary method of treatment for chondrosarcoma?

surgery

20

Chondrosarcoma develops in what age group?

30-60 yr olds

21

is Chondrosarcoma chemoresistant or chemosensitve?

chemoresistant

22

when is radiation therapy used for Chondrosarcoma

when the tumor cannot be completely removed

23

what part of the body is Ewings sarcoma most frequently found

lower 1/2 of the body

24

where is Ewings sarcoma most often found?

long bones and pelvis

25

what is the peak incidence for Ewings sarcoma?

mid teens, rare over 30

26

translocation of what two chromosomes are associated with Ewings sarcoma

22 & 11

27

what is the primary treatment for Ewings sarcoma

surgery, along with chemo and radiation to achive local control

28

what is Multiple myeloma?

malignant disease of the plasma cells

29

where does Multiple myeloma most often arise

B-cell lymphocytes of the bone marrow

30

the best treatment for Multiple myeloma is?

chemo and radition