Rheumatology Review Flashcards

1
Q

List the joints involved in osteoarthritis.

A

Heberden’s and Bouchard’s nodes, 1st MCP, hips, knees, spine, 1st MTP

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2
Q

Sports do not raise your risk of __________.

A

osteoarthritis

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3
Q

Osteoarthritis can result from metabolic disorders, such as _________.

A

hemochromatosis, Wilson’s, and ochronosis

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4
Q

TIMPs are _________; they will be decreased in _________.

A

tissue-inhibitors of metalloproteinases; osteoarthritis

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5
Q

There are no systemic features in ____________.

A

osteoarthritis

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6
Q

Prostaglandins, NO, and interleukin-1 stimulate _______ in osteoarthritis.

A

MMPs

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7
Q

List the joint distribution of rheumatoid arthritis.

A

Symmetric involvement of the small joints (with the exception of the DIPs); hips and knees may be involved

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8
Q

HLA-DR is a type of _______.

A

MHC II

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9
Q

The strongest genetic correlation with rheumatoid arthritis is ________.

A

QKRAA (a part of the third hypervariable region of HLA-DR4 and HLA-DR1)

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10
Q

Rheumatoid factor is produced in the _______; it is found in ____ percent of those with RA, but it is not specific to RA.

A

synovium; 85

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11
Q

________ is a more sensitive and specific test for RA.

A

Anti-CCP

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12
Q

The major type of cell in the synovial fluid of those with RA is ______.

A

neutrophils

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13
Q

Gout is _________ birefrigent., while CPDD is __________ birefrigent.

A

negatively; positively

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14
Q

Lesch-Nyhan is ______ recessive.

A

X-linked

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15
Q

CPDD results from ____________.

A

defects in the ANKH that causes chondrocytes to pump PPi into the synovium

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16
Q

Will spondyloarthropathies have ANA or RF?

A

No! But they will have increased TNFalpha in their joints

17
Q

Genetic association with SLE?

A

HLA-DR3 and C4 null allele

18
Q

cANCA is found in __________, while pANCA is found in __________.

A

GPA/Wegener’s; microscopic polyangiitis

19
Q

Polymyositis displays _______, while dermatomyositis displays ________.

A

CD8+; CD4+