Immunogenetics and Transplantation Flashcards

1
Q

The most important loci within the HLA loci are ________.

A

HLA-A, HLA-B (both of which are MHC II), and HLA-DR (MHC I)

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2
Q

The MHC set that you inherit from one parent is called a ______.

A

haplotype

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3
Q

In an MLR reaction, the _______ cells are treated to prevent division.

A

donor’s (because we just want to see if the recipients T cells will divide in response to the donor’s MHC)

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4
Q

Because of H-Y, _____ grafts will be rejected by ________.

A

male; females

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5
Q

Allografts are ___________.

A

transplants between non-identical members of the same species.

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6
Q

Xenografts are _____________.

A

transplants between members of different species

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7
Q

Isografts are _________.

A

grafts between identical twins

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8
Q

Autografts are __________.

A

transplants within the same individual

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9
Q

CTLs require both _____ and ____ to become activated.

A

IL-2; foreign cells/infected cells

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10
Q

Why is a good class II MHC activation important in a foreign-body situation?

A

Because class II activation (in Th1 cells) releases IL-2, an attractant for CTLs, and IFN-gamma, an attractant for macrophages

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