Hematopoiesis Flashcards
What is the most common site of hematopoiesis at four months’ gestation?
The liver
Sites of hematopoiesis in the bone marrow communicate with the blood vessels through ________ at sinusoids.
leaky blood vessels
Hematopoietic stem cells differentiate into ______ and _____.
myeloid stem cells; lymphoid stem cells
List the stages of hematopoiesis in a developing erythrocyte.
(1) Multipotent hematopoietic stem cell
(2) Myeloid stem cell
(3) Pronormoblast (or proerythroblast)
(4) Basophilic normoblast
(5) Polychromatophilic normoblast
(6) Orthochromatophilic normoblast
(7) Reticulocyte
(8) Erythrocyte
At which stage is the nucleus ejected in a developing erythrocyte?
Orthochromatophilic normoblast
The central pallor of a RBC should be roughly ___ the diameter of the cell.
1/3
Thrombopoietin is necessary for ______.
megakaryocyte maturation and platelet release
The largest hematopoietic cell is the ________.
megakaryocyte
List the stages of thrombopoiesis.
(1) Hematopoietic stem cell
(2) Myeloid stem cell
(3) Megakaryoblast
(4) Promegkaryocyte
(5) Megakaryocyte
(6) Platelet
What does G-CSF stand for?
Granulocyte Cell Stimulating Factor
List the stages of granulocyte development.
(1) Hematopoietic stem cell
(2) Myeloid stem cell
(3) Progenitor cell
(4) Myeloblast
(5) Promyelocyte
(6) Metamyelocyte
(7) Band
(8) Neutrophil, basophil, or eosinophil
What two cell signals are needed for mast cell differentiation?
Stem Cell Factor (SCF) and Interleukin-3 (IL-3)
B lymphoblasts develop into ______ and ______.
B cells and natural killer cells
The equation for cellularity of bone marrow is roughly _______.
100 - age
CFU-GEMM is _________.
the Colony-Forming Unit for Granulocytes/Erythrocytes/Monocytes/Megakaryocytes
