Final Exam Review

Question 1

Dactylitis is a sign of ___________.

Answer 1

reactive arthritis

Question 2

Lesch-Nyhan is deficiency of _________.

Answer 2

HGPRT

Question 3

The systemic effects of RA are mediated by ________.

Answer 3

IL-6

Question 4

Describe ANA.

Answer 4

ANA are high in asymptomatic people, so the lab value is not very useful for diagnosing stuff.

Question 5

Gout ______ have systemic symptoms.

Answer 5

can

Question 6

Those with HIV immunosuppression can still respond to __________.

Answer 6

extracellular pathogens

Question 7

Those with type I vWD have ______ factor VIII function.

Answer 7

55%

Question 8

In HIV, why do CD4+ cells lyse?

Answer 8

They lyse when virions bud.

Question 9

HIV elite controllers are ________ and make _________.

Answer 9

HLA-B57; more diversity of CTLs

Question 10

PPi levels are elevated in __________.

Answer 10

both CPDD and osteoarthritis

Question 11

Reactive arthritis presents with ________.

Answer 11

Reiter’s triad: conjunctivitis, urethritis, and arthritis

Question 12

Thrombin activates platelets by ___________.

Answer 12

cleaving protease activated receptor 1 (PAR1)

Question 13

Takayasu’s arteritis is shown by ___________.

Answer 13

fever, night sweats, skin nodules, weak pulses, ocular disturbances,

Question 14

RA begins with _________ and proceeds to _________.

Answer 14

inflammation of the synovium; arrival of type A and B cells and increase in synovial lining

Question 15

Platelet GP VI binds to __________.

Answer 15

collagen

Question 16

Only ______ percent of HLA-B27 people develop ankylosing spondylitis.

Answer 16

2

Question 17

Tumors that show embryonic antigens are _______.

Answer 17

oncofetal

Question 18

Western blots are more ______ than ELISA.

Answer 18

specific

Question 19

Chimeric antibodies can create a cytokine storm by ___________.

Answer 19

activating the CD3 receptor on T cells

Question 20

The severity of RA correlates with __________.

Answer 20

QKRAA in the HLA-DR4/HLA-DR1

Question 21

The earliest even in type III immune complexes is _________.

Answer 21

release of platelet-activating factors

Question 22

In chronic ITP, the only time platelets are transfused is _________.

Answer 22

in hemorrhagic emergencies

Question 23

People should stop taking aspirin _________ before a procedure.

Answer 23

10 days