Sickle Cell Disease Flashcards
Priapism is _________.
the state in which the erect penis does not return to its flaccid state
List the four effects that result from decreased NO activity (from hemolysis) in the arteries.
- priapism
- pulmonary hypertension
- leg ulcerations
- stroke
Polychromasia refers to _______.
large RBCs that have a bluish tint – indicative of reticulocytes
The most common complaint of those with sickle cell disease _________.
vaso-occlusive pain, a complication resulting in extensive pain from blocked blood vessels
Acute chest syndrome is _________.
occlusion of capillaries in the lungs resulting in edema
Sickle cell disease can result in splenic dysfunction, a state in which patients will be highly susceptible to _____.
infection from encapsulated bacteria (steptococcus pneumonaie, hemophilus influenzae, meningococcus)
Aplastic crisis, another potential consequence of sickle cell disease, involves infection by ______.
parvovirus B19
Splenic infarction happens when __________.
the capillary filters of the spleen get clogged and blood cannot flow through
Large-vessel strokes affect ____ of those with sickle cell, but evidence suggests ________ may be more common.
10%; silent ischemic attacks
Sickle nephropathy is present in _____ of those with SCD.
10% - 15%
Retinopathy, in which _______, is present in 11% - 45% of those with SCD.
vaso-occlusion in the eye produces retinal detachment and hemorrhage
_____ and _____ are also complications of SCD.
Avascular necrosis (resulting in bone atrophy); leg ulcers
Although hydroxyurea can help reduce acute pain and acute chest, it does not _______.
reduce chronic organ damage
Abnormal lab values in sickle cell anemia include _______.
increased WBC, RDW, and retic; abnormal smear
In SC patients, parvovirus B19 causes ______.
aplastic crisis due to impaired bone marrow response
