Type II Immunopathology - Autoimmunity

Question 1

Describe the pathology of Graves disease.

Answer 1

Antibodies act as agonists on the thyroid-stimulating hormone receptor, driving high levels of thyroid hormone.

Question 2

Type I immunopathology is _______.

Answer 2

mediated by IgE

Question 3

Type II immunpathology is ________.

Answer 3

mediated by IgA, IgG, and IgM

Question 4

Type III immunopathology is _________.

Answer 4

complexes of antibodies getting stuck in basement membranes, leading to vasculitis

Question 5

Type IV immunopathology is ___________.

Answer 5

T cell mediated

Question 6

Type V immunopathology (now a subset of type II) is _________.

Answer 6

when antibody binds to surface receptors

Question 7

Goodpasture syndrome results from ___________.

Answer 7

antibodies that attack the basement membrane of the renal tubules and the alveolae

Question 8

Idiopathic thrombocytopenia is know known to be _______.

Answer 8

autoimmune-mediated, as antibodies (usually after an infection) opsonize platelets; can be alleviated by immunosuppression or splenectomy

Question 9

Autoimmune hypothyroidism is known as ________.

Answer 9

Hashimoto’s (caused by antibodies to necessary thyroid components)

Question 10

Explain one mechanism by which B cells might be able to make antigen to self.

Answer 10

A B cell might be able to bind to a foreign protein attached to self protein (by binding its IgD to the self part) and then presenting