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Flashcards in Introduction to Fungi Deck (12)
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1

What is fungi

A chemo-organotrophic eukaryote which lacks chlorophyll and forms spores

2

What is the structure of fungi

Cell wall which contains polysaccharides (e.g. chitin or glucan) and absorbs nutrients
Membrane that contains ergosterol as major sterol

3

How are fungi classified

Principally based on morphology

4

What are the three groups that the fungal kingdom can be split into

Basidiomyceyes
Ascomycetes
Zygomycetes

5

What are yeasts

Fungi that favour a unicellular habit

6

Give an example of a dermatophytic fungal infection

Ringworm caused by tinea capitis, tinea facei, tinea barbae, tinea corporis. depending on the location on the body.

7

What is dermatophytosis

Moulds with a predilection to degrade keratin as a nutrient source

8

What host factors can contribute to the pathogenicity of fungal infections

Presence of a favourable micro-environment (warm, moist areas) will encourage the growth of fungi on skin and mucous membranes
Broad-spectrum antibacterial agents will reduce competition for epithelial colonization sites in the gut
Immunosuppression of all types (latrogenic e.g. steroids, chemo or disease processes e.g. AIDS, leukaemia) may create a window of opportunity for fungal invasion

9

Who can chronic mucocutaneous Candida infection affect

In individuals with an unusual combination of endocrine and immune dysfunction

10

How can fungi be detected

Direct detection using histopathology or high-res CT scans
Direct smear
Detection of the circulating fungal antigens
Detection of circulating antibodies to fungi
PCR for fungal DNA
Culture of fungus from normally sterile site

11

How do antifungals work

By causing membrane or cell wall stress

12

What are the problemss with antifungal treatment

Spectrum of activity
Static or cidal
IV vs oral
Toxicity
Cost