Introduction to Hematologic Malignancies Flashcards Preview

Lindsey's Blood and Lymph Unit III > Introduction to Hematologic Malignancies > Flashcards

Flashcards in Introduction to Hematologic Malignancies Deck (43)
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1

What is a disease of myeloid cells or precursors that is a solid mass?

extramedullary myeloid tumor aka granulocytic sarcoma

2

Which viruses are known to play a role in lymphoma genesis?

1. Epstein-Barr 2. human T cell leukemia virus-1 3. Kaposi sarcoma herpesvirus/human herpesvirus-8

3

What is grade?

the aggressiveness; rate of growth

3

Hematologic malignancies are divided into ____ or ____, where acute is used to describe the former and chronic for the latter.

high grade; low grade

4

Human T cell leukemia virus-1 (HTLV-1) can cause ____.

adult T cell leukemia/lymphoma (ATLL)

5

A _____ presents as a rapidly enlarging mass.

high grade lymphoma

5

_____ arise from B cell, T cell, or NK cell lineages.

Lymphoid malignancies

6

Kaposi sarcoma herpesvirus/human herpesvirus-8 can cause _____.

primary effusion lymphomas

7

_____ arise from granulocytic, monocytic, erythroid, megakaryocytic, and mast cell lineages.

Myeloid malignancies

8

Myeloid malignancies arise from ____, _____, _____, ____, and _____ lineages.

granulocytic, monocytic, erythroid, megakaryocytic, mast cell

9

What is mantle cell lymphoma?

lymphoma defined by t(11;14) involving IGH and CCND1 genes

9

What is CHL?

classical Hodgkin lymphoma; derived from B-cells, driven by Hodgkin-Reed-Sternberg (HRS) cells

10

extramedullary myeloid tumor

myeloid cells or precursors; solid mass

11

____ can cause primary effusion lymphomas.

Kaposi sarcoma herpesvirus/human herpesvirus-8

12

Hematologic malignancies are divided into high grade or low grade, where ____ is used to describe the former and ____ for the latter.

acute; chronic

13

another name for extramedullary myeloid tumor?

granulocytic sarcoma

13

____ has been known to cause classical Hodgkin lymphoma, some cases of Burkitt lymphoma, and some B-cell non-Hodgkin lymphoma.

Epstein-Barr virus

14

Epstein-Barr virus has been known to cause ____, ____, and _____.

classical Hodgkin lymphoma, some cases of Burkitt lymphoma, and some B-cell non-Hodgkin lymphoma

14

What is plasma cell neoplasm?

includes MGUS, plasmacytoma, and multiple myeloma

16

How is a low grade leukemia detected?

incidentally via CBC

17

How are acute leukemias evaluated?

1. morphology 2. immunophenotyping (flow cytometry and immunohistochemistry)

19

A _____ presents as a very high WBC.

high grade/acute leukemia

20

Acute leukemias are due to?

rapid accumulation of (usually) immature cells in the marrow

21

lymphoma

lymphocytes or precursors; solid mass

22

What is NHL?

non-Hodgkin lymphoma; any malignancy derived from B cells, T cells, or NK cells

23

What are MPNs?

myeloproliferative neoplasms; bone marrow makes too many normal cells

24

What are the 1st and 3rd most common childhood cancers, respectively?

leukemia; lymphoma

26

granulocytic sarcoma

myeloid cells or precursors; solid mass

27

What is a precursor to AML?

myelodyplastic syndrome (MDS); sometimes myeloproliferative neoplasms (MPNs)

29

A _____ presents as a mildly enlarged neck lymph node that has been present for years.

low grade lymphoma