What are the treatments of Dressler Syndrome?
What is rheumatoid factor (RF)?
IgM anti-IgG in RA
People with SLE can make autoantibodies to _____, ____, ____, _____, _____, _____, _____, and _____.
nuclear proteins, DNA, RNA, RBCs, clotting factors, platelets, skin, T cells
When can passive antibodies cause diseases?
1. hemolytic disease of the newborn 2. mismatched transfusions 3. children of mothers with myasthenia gravis or SLE
Who gets Autoimmune Hemolytic Anemia (AIHA)?
pts who recently had a viral infection; have a different autoimmune disease; hx of cancer
How does the immunofluorescence appear in Goodpasture Syndrome cells?
What are the s/s of Goodpasture Syndrome?
persistent glomerularnephritis, pneumonitis, pulmonary hemmorhages
What is Dressler Syndrome?
autoantibodies to the heart post MI or heart surgery
Platelets are phagocytosed via _____ damage in autoimmune thrombocytopenic purpura.
What is Goodpasture Syndrome?
autoantibodies to lung and kidney BM
What is chronic beryllium disease (CBD)?
an allergic response and lung disease due to beryllium exposure/poisoning
What is a good diagnostic marker in Celiac disease?
antibody to tissue transglutaminase
What causes Rheumatic Heart Disease?
a cross reaction of group A strep M-protein antigen and laminin on heart valves, followed by neutrophil-mediated tissue destruction
SLE is much more common in ____, pointing to an ____ effect.
Dressler Syndrome is seen in _____.
patients who had a MI or heart surgery
If you have a sample of the patient's tissue, you can use the _____ test for autoimmunity.
What is the treatment for inappropriate tachycardia?
a beta blocker (propranolol)
What is a sequestered antigen?
antigens that cannot get into the system until an immune response is started in another way
What is stimulatory hypersensitivity?
autoantibody to receptor activates it (agonist)
What is the hallmark test for autoimmunity?
What is Aire?
a thymic transcription factor
What is an innocent bystander?
normal tissue that is damaged because it's near or associated with antigen
Name a physical sign characteristic of SLE.
facial butterfly rash
RA is linked to the gene _____.
How does complement-mediated damage harm tissue?
lysis, phagocytosis, lysosomal enzymes and ROS
Why do disease states persist, even when the initial antigen is long gone?
autoimmune responses to normally sequestered antigens released from damaged cells
Lysis of ____ occurs in autoimmune hemolytic anemia via complement-mediated damage.
If you have a sample of the patient's serum, you can use the _____ test for autoimmunity.
What are the hallmarks of type 2 immune diseases?
1. IgG, IgM, or IgA autoantibody mediated (harm to self) 2. can stimulate or damage the cell
Lysis of RBCs occurs in _____ via complement-mediated damage.
autoimmune hemolytic anemia