Immunopathology Type 4, Immune Regulation Flashcards Preview

Lindsey's Blood and Lymph Unit III > Immunopathology Type 4, Immune Regulation > Flashcards

Flashcards in Immunopathology Type 4, Immune Regulation Deck (76)
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1

Where do dendritic cells present antigen?

in the lymph nodes

1

One activated Th1 cell can attract ____ macs.

1000

2

What is the frequency of abacavir hypersensitivity syndrome and what do we do bc of this?

8% of recipients; test for allele before giving drug (personalized medicine)

2

What is the first set reaction?

rejection in 10-20 days; 5-10% of T cells react to the foreign MHC

2

What are the s/s of Acute GvHD?

maculopapular skin rash, diarrhea, hepatic inflammation, jaundice, infections

2

What prevents Acute GvHD?

removing T cells from the bone marrow

3

What is a hyperacute/white graft reaction?

rejection before the graft even heals in- remains white and bloodless- from putting same graft in multiple times- due to Abs and histocompatibility antigens

5

What is the initiation of an immune response?

first exposure- immunization phase

5

HLA-B*1502 is assoc. with _____.

drug-induced hypersensitivity by carbamazepine

5

What is the HLA assoc. in T1D?

HLA-DR3 and HLA-DR4

5

What is Acute GvHD?

bone marrow rejection 2-10 weeks post transplant

6

Why doesn't the graft usually win when it tries to reject the host? When does the graft actually win?

it's smaller than the host, which overcomes it; immunocompetent host

7

What happens to cause T1D?

antibodies to beta-cells

8

What does a Th1 activation by M. leprae cause?

tuberculoid leprosy with large skin and nerve lesions, but they contain the infection

9

What is the assoc. allele in carbamazepine hypersensitivity?

HLA-B*1502

9

What is a xenograft?

from another species

9

What does Chronic GvHD sometimes cause?

autoimmunity

10

What is the treatment for contact dermatitis?

avoidance, topical steroids

10

Why does a graft-vs-host reaction occur?

graft contains T cells that, when transplanted, recognize the HLA on the recipient as foreign- the graft tries to reject the hose

10

What does a Th1 activation by M. leprae cause?

tuberculoid leprosy with large skin and nerve lesions, but they contain the infection

11

What is delayed-type hypersensitivity (DTH)?

T-cell mediated events that are undesirable or injurious

12

What genes are thought to be the problem in T1D?

DQ genes

12

What is the treatment for Acute GvHD?

anti-inflammatories; corticosteroids; immunosuppressives

13

What is MS?

demyelinating disease- T cell reactivity to autoantigen

15

Who does the dendritic cell present its MHC+antigen to?

Th0 precursors

16

What are treatments for MS?

1. natalizumab (humanized monoclonal Ab) 2. rituximab (monoclonal Ab to B cells)

17

What are the characteristics of memory T cells?

more numerous in exposed person; lower activation threshold

18

What recognizes HLA-B5701 and why?

Th1 bc it's a class I MHC

19

What is Hashimoto Thyroiditis?

destructive attack of the thyroid by T cells; most common cause of hypothyroidism

20

There are 9 examples of pathologies where Type IV is the causative mechanism. List?

1. rejection of allographs 2. graft-vs-host disease 3. positive Tb test 4. resistance to Myco. tb 5. resistance to fungal infections 6. contact dermatitis (poison ivy) 7. chronic beryllium disease 8. autoimmune diseases (MS) 9.tumor immunity