Immunopathology Type 1, Allergies Flashcards
What fights parasites in the body?
Th2, IgE, IgG
What is IgG’s role in fighting worms?
binds the worm or ova and activates complement
What happens when neutrophils respond to the opsonized worms?
nothing- they lack a helminthocidal mechanism
How are mast cells activate by worms?
worms secrete antigen that diffuse to the mast cells, activating them
How does mast cell degranulation help fight worms?
histamine causes smooth muscle contraction; violent peristalsis expels the worms
What do mast cells secrete to attract eos?
prostaglandins and leukotrienes
Why do mast cells secrete prostaglandins and leukotrienes?
to attract eos
What happens when an eosinophil engages an IgG opsonized worm?
it releases its granules, including Major Basic Protein
What is Major Basic Protein?
a granule secreted by eos that is highly toxic to helminths
What is the Th2’s role in worm fighting?
it attracts both eos and macs and secretes IL-4, 5, and 13 to convert the macs to M2 macs
Why do Th2 cells convert macs into M2 macs in worm infections?
to heal damage and wall off the worm
____ binds strongly to the FceR1 receptors on mast cells.
IgE
IgE binds strongly to the _____ on mast cells.
FceR1 receptors
IgE binds strongly to the FceR1 receptors on ____.
mast cells
When _____ are cross linked by an allergen, the mast cell degranulates.
2 adjacent bound IgE molecules
