Deficiency of Adaptive Immunity (Immune Deficiencies) Flashcards Preview

Lindsey's Blood and Lymph Unit III > Deficiency of Adaptive Immunity (Immune Deficiencies) > Flashcards

Flashcards in Deficiency of Adaptive Immunity (Immune Deficiencies) Deck (67)
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1

What is the incidence rate of X-linked (Bruton) Agammaglobulinemia?

0.4/100,000

1

Which cell induces class switching in the B cell?

Tfh

1

Name 2 advanced tests for phagocyte presence/function.

1. assays for phagocytosis, chemotaxis 2. genetics

3

What is a secondary immunodeficiency?

a process outside of the immune system has caused the problem

4

What enzyme to SCID pts lack?

adenosine deaminase (ADA)

4

What is the syndrome called where pts have high IgM with low IgG and IgA?

X-linked hyperIgM syndrome

4

People with CVID are at increased risk for ____, ____, and ____.

lymphoma, enteropathy, autoimmunity

5

T-cell deficiencies are assoc. with intracellular pathogens, especially _____ and _____.

Candida albicans; Pnemocystis jirovecii

6

What is the defect in X-linked hyperIgM syndrome?

IgM-to-IgG switch mechanism

6

___ deficiencies are assoc. with high grade bacterial infections, such as Staph. aureus, H. influenzae, and Strep. pneumoniae.

B-cell

7

What is the syndrome where the thymus develops abnormally, resulting in absent T cells and normal B cells?

DiGeorge Syndrome

8

Name 2 initial tests for phagocyte presence/function.

1. WBC count, diff, morph 2. NBT test, oxidative burst

9

B-cell deficiencies are assoc. with ____, such as Staph. aureus, H. influenzae, and Strep. pneumoniae.

high grade bacterial infections

10

How is AT inherited?

auto recessive

11

How is Wiskott-Aldrich syndrome inherited?

X-linked

13

What role does adenosine play in cellular development?

it accumulates in all cells, but impairs lymphocyte development in most severe

14

What is the cause of DiGeorge Syndrome?

large (45 gene) deletion on chromosome 22

14

What is the most common disease of immunodeficiency, and what is the incidence rate?

Selective IgA deficiency; 1/500

15

Name 4 initial tests for B cell presence/function.

1. serum protein electrophoresis 2. quantitative IgG, A, M levels 3. specific Abs to prior immunizations 4. ABO isohemagglutinins

17

What is the life span of a pt with SCID?

1 year

18

Name 2 advanced tests for T cell presence/function.

1. CD3, CD4, CD8 counts 2. mitogen responses, MLR, cytokine measurements

18

Name an advanced test for complement presence/function.

1. individual complement component levels

19

AT patients have a very high rate of tumors because of?

defective DNA repair

21

What ligand does the Tfh cell interact with on the B cell?

CD40

22

What is the most common form of SCID in Navajo children and what is the incidence rate?

defect in V(D)J recombination; 50/100,000

22

What are the s/s/findings in SCID?

lymphopenia of both T and B cells; absent thymic shadows; small tonsils; serum immunoglobulins are low

23

Primary immunodeficiencies affect ____ cells.

T or B, or both,

23

What is common variable immunodeficiency (CVID)?

B cells are difficult to trigger specific antibody; serum IgG low

24

What is telangiectasia?

dilated abnormal blood vessels

25

What is Transient Hypogammaglobinemia of Infancy?

slow IgG build up in affected children